vandetanib

kinase insert domain receptor ; Homo sapiens







115 Article(s)
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51 22715896 Vandetanib: in medullary thyroid cancer. 2012 Jul 9 1
52 22898678 Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 2 trial. 2012 Sep 1
53 20665703 ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells. 2011 Feb 2
54 21247406 Emerging therapies in the treatment of locally advanced squamous cell cancers of head and neck. 2011 May 2
55 21350000 Vandetanib restores head and neck squamous cell carcinoma cells' sensitivity to cisplatin and radiation in vivo and in vitro. 2011 Apr 1 2
56 21410294 Pharmacokinetic drug interactions with vandetanib during coadministration with rifampicin or itraconazole. 2011 1
57 21537841 Vandetanib inhibits both VEGFR-2 and EGFR signalling at clinically relevant drug levels in preclinical models of human cancer. 2011 Jul 5
58 21549594 Radiosynthesis of [11C]Vandetanib and [11C]chloro-Vandetanib as new potential PET agents for imaging of VEGFR in cancer. 2011 Jun 1 4
59 21770481 Vandetanib: first global approval. 2011 Jul 9 1
60 21819274 Vandetanib for the treatment of non-small-cell lung cancer. 2011 Oct 1
61 21836817 Vandetanib (ZD6474) in the Treatment of Medullary Thyroid Cancer. 2011 4
62 22346266 Photosensitivity reactions to vandetanib: redevelopment after sequential treatment with docetaxel. 2011 Dec 2
63 22393954 Efficacy and safety of vandetanib, a dual VEGFR and EGFR inhibitor, in advanced non-small-cell lung cancer: a systematic review and meta-analysis. 2011 1
64 20068097 Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2. 2010 Jan 15 1
65 20137866 Phase I study of vandetanib with radiotherapy and temozolomide for newly diagnosed glioblastoma. 2010 Sep 1 1
66 20139705 ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. 2010 Apr 15 4
67 20371662 Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. 2010 Jun 1
68 20371720 ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain. 2010 Apr 2
69 20570559 Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. 2010 Jul 2
70 20859451 Current status of vandetanib (ZD6474) in the treatment of non-small cell lung cancer. 2010 Sep 13 4
71 20868411 Therapeutic hotline. A rare vandetanib-induced photo-allergic drug eruption. 2010 Sep-Oct 1
72 20921456 Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma. 2010 Nov 1 1
73 20967300 Vandetanib: An overview of its clinical development in NSCLC and other tumors. 2010 Sep 2
74 19211364 [Advances in the treatment of thyroid cancer in the era of molecularly targeted therapies]. 2009 Jan 1
75 19318229 Growth inhibition by tyrosine kinase inhibitors in mesothelioma cell lines. 2009 Jun 1
76 19319137 Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma. 2009 Apr 21 3
77 19332730 Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase ii study. 2009 May 20 3
78 19349511 Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions. 2009 Apr 5
79 19491268 Effects of vandetanib on lung adenocarcinoma cells harboring epidermal growth factor receptor T790M mutation in vivo. 2009 Jun 15 3
80 19512898 Corneal verticillata after dual anti-epidermal growth factor receptor and anti-vascular endothelial growth factor receptor 2 therapy (vandetanib) for anaplastic astrocytoma. 2009 Jul 3
81 19946413 DCE-MRI assessment of the effect of vandetanib on tumor vasculature in patients with advanced colorectal cancer and liver metastases: a randomized phase I study. 2009 Sep 21 1
82 17393165 Dose scheduling of the dual VEGFR and EGFR tyrosine kinase inhibitor vandetanib (ZD6474, Zactima) in combination with radiotherapy in EGFR-positive and EGFR-null human head and neck tumor xenografts. 2008 Feb 6
83 18177496 Proliferation of Ewing sarcoma cell lines is suppressed by the receptor tyrosine kinase inhibitors gefitinib and vandetanib. 2008 Jan 4 2
84 18347145 Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice. 2008 Mar 2
85 18364248 Novel dual targeting strategy with vandetanib induces tumor cell apoptosis and inhibits angiogenesis in malignant pleural mesothelioma cells expressing RET oncogenic rearrangement. 2008 Jun 28 2
86 18379357 A randomized, double-blind, phase IIa dose-finding study of Vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer. 2008 Apr 2
87 18687659 Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib. 2008 Aug 1
88 21479415 Antitumor activity of ZD6474 in a metastatic orthotopic brain tumor model. 2008 May-Jun 2
89 17203163 Antitumor effects of ZD6474 on head and neck squamous cell carcinoma. 2007 Feb 3
90 17243944 Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis. 2007 Feb 1
91 17272980 Combined targeted therapies in non-small cell lung cancer: a winner strategy? 2007 Mar 1
92 17308046 Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade. 2007 Feb 3
93 17414626 Antiangiogenic and antitumor activity of a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ZD6474 in a metastatic human pancreatic tumor model. 2007 Jun 2
94 17631646 Induction of cell cycle arrest and apoptosis in human nasopharyngeal carcinoma cells by ZD6474, an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase. 2007 Nov 1 3
95 17671152 Vascular endothelial growth factor receptor tyrosine kinase inhibitors vandetanib (ZD6474) and AZD2171 in lung cancer. 2007 Aug 1 2
96 17878479 Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. 2007 Sep 20 1
97 17889445 Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer. 2007 Dec 1 3
98 16377413 ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinase activity in combination with radiotherapy. 2006 Jan 1 1
99 16688779 Anti-tumor activity of the combination of cetuximab, an anti-EGFR blocking monoclonal antibody and ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinases. 2006 Aug 3
100 16783964 ZD6474, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, inhibits growth of experimental lung metastasis and production of malignant pleural effusions in a non-small cell lung cancer model. 2006 5