Title : Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma.

Pub. Date : 2010 Nov 1

PMID : 20921456






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1 PURPOSE: To evaluate the safety, maximum-tolerated dose, pharmacokinetics, and pharmacodynamics of vandetanib, an oral vascular endothelial growth factor receptor 2 (VEGFR2) and epidermal growth factor receptor inhibitor, administered once daily during and after radiotherapy in children with newly diagnosed diffuse intrinsic pontine glioma. vandetanib kinase insert domain receptor Homo sapiens