Pub. Date : 2010 Apr 15
PMID : 20139705
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. | vandetanib | kinase insert domain receptor | Homo sapiens |
2 | Consequently, the dual kinase inhibitor of EGFR and VEGFR ZD6474 represents a promising biologically-based treatment that is currently undergoing clinical trials for non-small cell lung cancer. | vandetanib | kinase insert domain receptor | Homo sapiens |
3 | We hypothesized that inhibition of phosphorylation of the EGFR and VEGFR by ZD6474 would inhibit breast cancer cell proliferation and induce apoptosis. | vandetanib | kinase insert domain receptor | Homo sapiens |
4 | ZD6474 inhibited cell proliferation in a dose-dependent manner, by blocking cell progression at the G(0)-G(1) stage, through downregulation of expression of cyclin D1 and cyclin E. In vitro, ZD6474 inhibited growth factor-induced phosphorylation of EGFR, VEGFR-2, MAPK and Akt. | vandetanib | kinase insert domain receptor | Homo sapiens |