2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

mitogen-activated protein kinase 3 ; Homo sapiens







106 Article(s)
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51 21904903 PI3K/Akt and MAPK/ERK1/2 signaling pathways are involved in IGF-1-induced VEGF-C upregulation in breast cancer. 2011 Nov 1
52 21948550 Human corneal endothelial cells employ phosphorylation of p27(Kip1) at both Ser10 and Thr187 sites for FGF-2-mediated cell proliferation via PI 3-kinase. 2011 Oct 17 3
53 19882665 The EGF receptor-sox2-EGF receptor feedback loop positively regulates the self-renewal of neural precursor cells. 2010 Feb 1
54 20135719 Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion. 2010 Feb 14 1
55 20506505 Overexpression of fucosyltransferase IV promotes A431 cell proliferation through activating MAPK and PI3K/Akt signaling pathways. 2010 Nov 1
56 20855443 Down-regulation of Rad51 expression overcomes drug resistance to gemcitabine in human non-small-cell lung cancer cells. 2010 Dec 1
57 18941890 Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha. 2009 Nov 1
58 19143758 TGFbeta inhibits GM-CSF-induced phosphorylation of ERK and MEK in human myeloid leukaemia cell lines via inhibition of phosphatidylinositol 3-kinase (PI3-k). 2009 Feb 1
59 19328461 ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells. 2009 1
60 19406941 Activation of the lutropin/choriogonadotropin receptor inhibits apoptosis of immature Leydig cells in primary culture. 2009 Aug 2
61 19428994 Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism. 2009 May 6 1
62 19443725 Dependence of EGF-induced increases in corneal epithelial proliferation and migration on GSK-3 inactivation. 2009 Oct 1
63 19610136 Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. 2009 Jul 21 1
64 19711359 Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death. 2009 Dec 1
65 19892399 Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation: roles of MEK1/2/ERK1/2 and PI3K/AKT1 pathways. 2009 Dec 1
66 18315925 Brain derived neurotrophic factor induces endothelial cells angiogenesis through AKT and ERK1/2 signal pathway. 2008 Feb 1
67 18341625 Mitogenic and anti-apoptotic actions of adipocyte-derived hormone leptin in prostate cancer cells. 2008 Aug 1
68 18425342 Constitutive activation of p70 S6 kinase is associated with intrinsic resistance to cisplatin. 2008 May 1
69 17234779 Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. 2007 Jan 15 1
70 17473185 Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells. 2007 May 1 1
71 17539658 Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling. 2007 Jun 27 1
72 16394177 Protein kinase C (PKC)-delta/-epsilon mediate the PKC/Akt-dependent phosphorylation of extracellular signal-regulated kinases 1 and 2 in MCF-7 cells stimulated by bradykinin. 2006 Jan 1
73 16406609 PI3K is required for insulin-stimulated but not EGF-stimulated ERK1/2 activation. 2006 May 1
74 16884765 Stromal cell-derived factor 1alpha stimulates human endometrial carcinoma cell growth through the activation of both extracellular signal-regulated kinase 1/2 and Akt. 2006 Dec 1
75 17068339 Dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2. 2006 Dec 22 1
76 15715661 Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells. 2005 Mar 1
77 15833899 Suramin promotes proliferation and scattering of renal epithelial cells. 2005 Jul 1
78 15857748 Effects of FSH and 17beta-estradiol on the transactivation of estrogen-regulated promoters and cell proliferation in L cells. 2005 Mar 1
79 15934945 NT3 inhibits FGF2-induced neural progenitor cell proliferation via the PI3K/GSK3 pathway. 2005 Jun 1
80 15947112 Gonadotropins upregulate the epidermal growth factor receptor through activation of mitogen-activated protein kinases and phosphatidyl-inositol-3-kinase in human ovarian surface epithelial cells. 2005 Jun 1
81 15947481 The synthetic chemoattractant peptide WKYMVm induces superoxide production by human eosinophils via the phosphoinositide 3-kinase-mediated activation of ERK1/2. 2005 1
82 16036314 Effects of pulsatile shear stress on signaling mechanisms controlling nitric oxide production, endothelial nitric oxide synthase phosphorylation, and expression in ovine fetoplacental artery endothelial cells. 2005 Jan-Apr 1
83 16128807 Acute activation of Erk1/Erk2 and protein kinase B/akt proceed by independent pathways in multiple cell types. 2005 Sep 1
84 16135959 Peptidoglycan of Staphylococcus aureus induces enhanced levels of matrix metalloproteinase-9 in human blood originating from neutrophils. 2005 Sep 1
85 14715711 Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase- and phosphatidylinositol 3-kinase-dependent signaling pathways. 2004 Apr 1
86 14729104 Activation of ERK1/2, JNK and PKB by hydrogen peroxide in human SH-SY5Y neuroblastoma cells: role of ERK1/2 in H2O2-induced cell death. 2004 Jan 12 1
87 15020266 Promyelocytic leukemia retinoid signaling targets regulate apoptosis,tissue factor and thrombomodulin expression. 2004 Mar 1
88 15313431 C5a differentially stimulates the ERK1/2 and p38 MAPK phosphorylation through independent signaling pathways to induced chemotactic migration in RAW264.7 macrophages. 2004 Oct 1
89 12589789 Interleukin 15 induces the signals of epidermal proliferation through ERK and PI 3-kinase in a human epidermal keratinocyte cell line, HaCaT. 2003 Feb 21 1
90 14516795 Hydrogen peroxide mediates arsenite activation of p70(s6k) and extracellular signal-regulated kinase. 2003 Oct 15 2
91 11902114 Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones. 2002 Jan 1
92 12105209 Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression. 2002 Sep 20 1
93 12393899 ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. 2002 Dec 20 1
94 12444071 Embryonic testis cord formation and mesonephric cell migration requires the phosphotidylinositol 3-kinase signaling pathway. 2002 Dec 1
95 11226388 Regulation of p42/p44 MAPK and p38 MAPK by the adenosine A(1) receptor in DDT(1)MF-2 cells. 2001 Feb 16 2
96 11267999 P2Y(2) nucleotide receptor signaling in human monocytic cells: activation, desensitization and coupling to mitogen-activated protein kinases. 2001 May 1
97 11335710 Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2. 2001 Jun 29 1
98 11422447 Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts. 2001 Jun 1
99 10979966 Phosphatidylinositol-3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils. 2000 Sep 15 1
100 9882612 Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase. 1999 Jan 15 1