Title : Phosphatidylinositol-3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils.

Pub. Date : 2000 Sep 15

PMID : 10979966






1 Functional Relationships(s)
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1 Inhibition of PI3 kinase by selective inhibitor (LY294002) abolished anti-IgE antibody- but not FMLP-induced phosphorylation of MEK1 (MAPK kinase/ERK kinase) and ERKs while inhibiting LTC4 generation as well as histamine release. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one mitogen-activated protein kinase 3 Homo sapiens