Title : The EGF receptor-sox2-EGF receptor feedback loop positively regulates the self-renewal of neural precursor cells.

Pub. Date : 2010 Feb

PMID : 19882665






1 Functional Relationships(s)
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1 Moreover, the effect of Sox2 on NPC self-renewal is completely inhibited by AG1478, a specific inhibitor for Egfr; it is also inhibited by LY294002 and U0126, selective antagonists for phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated kinase (Erk1/2), respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one mitogen-activated protein kinase 3 Homo sapiens