| 1 |
35472745 | Combined inhibition of BET bromodomain and mTORC1/2 provides therapeutic advantage for rhabdomyosarcoma by switching cell death mechanism. | 2022 Apr 26 |
1 |
| 2 |
33222668 | OSI-027 Alleviates Oxaliplatin Chemoresistance in Gastric Cancer Cells by Suppressing P-gp Induction. | 2021 |
2 |
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33836346 | Effects of rapamycin and OSI-027 on α-SMA in lung tissue of SD rat pups with hyperoxic lung injury. | 2021 Jun 4 |
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| 4 |
30650200 | Targeting mTORC1/2 with OSI-027 inhibits proliferation and migration of keloid keratinocytes. | 2019 Mar |
1 |
| 5 |
27002938 | A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies. | 2016 Apr 12 |
2 |
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27212159 | Inhibition of mTOR suppresses human gallbladder carcinoma cell proliferation and enhances the cytotoxicity of 5-fluorouracil by downregulating MDR1 expression. | 2016 May |
1 |
| 7 |
26026051 | Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC Cells. | 2015 Aug |
3 |
| 8 |
26213847 | OSI-027 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine both in vitro and in vivo. | 2015 Sep 22 |
1 |
| 9 |
26284306 | The Antipancreatic Cancer Activity of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2. | 2015 Oct |
3 |
| 10 |
22080480 | Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies. | 2012 Jan 12 |
2 |
| 11 |
21363918 | Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors. | 2011 Mar 1 |
1 |
| 12 |
21415215 | Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors. | 2011 Jul 1 |
1 |
| 13 |
21673091 | Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. | 2011 Aug |
3 |
| 14 |
20616057 | Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells. | 2010 Jul 13 |
1 |
| 15 |
20699667 | Induction of autophagy by dual mTORC1-mTORC2 inhibition in BCR-ABL-expressing leukemic cells. | 2010 Oct |
1 |