Pub. Date : 2016 Apr 12
PMID : 27002938
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies. | OSI 027 | CREB regulated transcription coactivator 2 | Mus musculus |
| 2 | CONCLUSIONS: OSI-027 inhibits mTORC1/2 in patients with advanced tumour s in a dose-dependent manner but doses above the tolerable levels in S1 and S3 are required for a sustained biological effect in tumour biopsies. | OSI 027 | CREB regulated transcription coactivator 2 | Mus musculus |