Title : OSI-027 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine both in vitro and in vivo.

Pub. Date : 2015 Sep 22

PMID : 26213847






1 Functional Relationships(s)
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1 In this study, we investigated the in vitro efficacy of OSI-027, a selective inhibitor of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2, to treat PDAC cell lines alone, and in combination with gemcitabine (GEM). OSI 027 CREB regulated transcription coactivator 2 Mus musculus