Pub. Date : 2015 Oct
PMID : 26284306
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Antipancreatic Cancer Activity of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2. | OSI 027 | CREB regulated transcription coactivator 2 | Mus musculus |
| 2 | In the present study, we investigated the potential activity of OSI-027, a potent and selective mammalian target of rapamycin (mTOR) complex 1/2 (mTORC1/2) dual inhibitor, against pancreatic cancer cells both in vitro and in vivo. | OSI 027 | CREB regulated transcription coactivator 2 | Mus musculus |
| 3 | At the molecular level, OSI-027 treatment blocked mTORC1 and mTORC2 activation simultaneously, without affecting ERK-mitogen-activated protein kinase activation. | OSI 027 | CREB regulated transcription coactivator 2 | Mus musculus |