Metformin

mechanistic target of rapamycin kinase ; Homo sapiens







361 Article(s)
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51 34351835 Therapeutic perspectives on the metabolism of lymphocytes in patients with rheumatoid arthritis and systemic lupus erythematosus. 2021 Oct 1
52 34421608 Metformin Potentiates the Effects of Anlotinib in NSCLC via AMPK/mTOR and ROS-Mediated Signaling Pathways. 2021 4
53 34422646 The Effects of NT-1044, a Novel AMPK Activator, on Endometrial Cancer Cell Proliferation, Apoptosis, Cell Stress and In Vivo Tumor Growth. 2021 1
54 34432352 Pretreatment with metformin prevents microcystin-LR-induced tau hyperphosphorylation via mTOR-dependent PP2A and GSK-3β activation. 2021 Dec 2
55 34434111 Metformin Attenuates Silica-Induced Pulmonary Fibrosis by Activating Autophagy via the AMPK-mTOR Signaling Pathway. 2021 4
56 34440224 Clinical Implication of Metformin in Relation to Diabetes Mellitus and Ovarian Cancer. 2021 Aug 16 1
57 34479029 Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses. 2021 Nov 2
58 34481229 Estradiol ameliorates metformin-inhibited Sertoli cell proliferation via AMPK/TSC2/mTOR signaling pathway. 2021 Nov 3
59 34486387 Metformin Rescues the Impaired Osteogenesis Differentiation Ability of Rat Adipose-Derived Stem Cells in High Glucose by Activating Autophagy. 2021 Oct 15 1
60 34576192 Metformin and Dichloroacetate Suppress Proliferation of Liver Cancer Cells by Inhibiting mTOR Complex 1. 2021 Sep 17 1
61 34607979 Knockdown of LKB1 Sensitizes Endometrial Cancer Cells via AMPK Activation. 2021 Nov 1 1
62 34628168 Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential. 2021 Dec 1
63 34664036 A review on protective roles and potential mechanisms of metformin in diabetic patients diagnosed with COVID-19. 2021 Dec 1
64 34690930 Interaction of Severe Acute Respiratory Syndrome Coronavirus 2 and Diabetes. 2021 1
65 34745769 Metformin promotes anticancer activity of NK cells in a p38 MAPK dependent manner. 2021 1
66 34944598 Metformin Improves Stemness of Human Adipose-Derived Stem Cells by Downmodulation of Mechanistic Target of Rapamycin (mTOR) and Extracellular Signal-Regulated Kinase (ERK) Signaling. 2021 Nov 27 4
67 31570268 Phase 1 Study of Erlotinib and Metformin in Metastatic Triple-Negative Breast Cancer. 2020 Feb 1
68 31789625 Metformin mediated microRNA-7 upregulation inhibits growth, migration, and invasion of non-small cell lung cancer A549 cells. 2020 Apr 2
69 31830378 Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway. 2020 Feb 3
70 31874705 Metformin reduces prion infection in neuronal cells by enhancing autophagy. 2020 Mar 5 1
71 31902918 Metformin Suppresses LPS-Induced Inflammatory Responses in Macrophage and Ameliorates Allergic Contact Dermatitis in Mice via Autophagy. 2020 2
72 31926250 Inhibition of mTORC1/P70S6K pathway by Metformin synergistically sensitizes Acute Myeloid Leukemia to Ara-C. 2020 Feb 15 1
73 32048246 Metformin accelerates myelin recovery and ameliorates behavioral deficits in the animal model of multiple sclerosis via adjustment of AMPK/Nrf2/mTOR signaling and maintenance of endogenous oligodendrogenesis during brain self-repairing period. 2020 Jun 4
74 32068959 The Aging Metabolome-Biomarkers to Hub Metabolites. 2020 Mar 1
75 32099330 Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis. 2020 3
76 32183017 Metformin as an Adjuvant to Photodynamic Therapy in Resistant Basal Cell Carcinoma Cells. 2020 Mar 13 2
77 32229782 Metformin as an Alternative Radiosensitizing Agent to 5-Fluorouracil During Neoadjuvant Treatment for Rectal Cancer. 2020 Jul 1
78 32248762 Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats. 2020 Apr 7 1
79 32251713 A novel insight into the anticancer mechanism of metformin in pancreatic neuroendocrine tumor cells. 2020 Jun 1 1
80 32341701 The Influence of Metformin to the Transcriptional Activity of the mTOR and FOX3 Genes in Parapancreatic Adipose Tissue of Streptozotocin-Induced Diabetic Rats. 2020 Jan-Mar 1
81 32443566 Metformin: Sentinel of the Epigenetic Landscapes That Underlie Cell Fate and Identity. 2020 May 18 1
82 32460059 Metformin suppresses the growth of leukemia cells partly through downregulation of AXL receptor tyrosine kinase. 2020 Jul 3
83 32470453 The impact of metformin and aspirin on T-cell mediated inflammation: A systematic review of in vitro and in vivo findings. 2020 Aug 15 2
84 32495867 Metformin reduces pancreatic cancer cell proliferation and increases apoptosis through MTOR signaling pathway and its dose-effect relationship. 2020 May 4
85 32547075 Metformin Promotes Beclin1-Dependent Autophagy to Inhibit the Progression of Gastric Cancer. 2020 2
86 32589349 Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells. 2020 Oct 1
87 32601620 Prospective Evaluation of Effect of Metformin on Activation of AMP-activated Protein Kinase (AMPK) and Disease Control in a Sub-group Analysis of Patients with GI Malignancies. 2020 2
88 32627027 Metformin inhibits TGF‑β1‑induced epithelial‑mesenchymal transition and liver metastasis of pancreatic cancer cells. 2020 Jul 7
89 32734128 Antitumor Activity of Combination Therapy with Metformin and Trametinib in Non-Small Cell Lung Cancer Cells. 2020 Jun 4
90 32748870 Metformin and Everolimus: A Promising Combination for Neuroendocrine Tumors Treatment. 2020 Aug 2 3
91 32765083 Metformin Induces Autophagy via the AMPK-mTOR Signaling Pathway in Human Hepatocellular Carcinoma Cells. 2020 4
92 32825760 Metformin Restores the Drug Sensitivity of MCF-7 Cells Resistant Derivates via the Cooperative Modulation of Growth and Apoptotic-Related Pathways. 2020 Aug 21 2
93 32825834 Neoadjuvant metformin added to conventional chemotherapy synergizes anti-proliferative effects in ovarian cancer. 2020 Aug 21 2
94 32861747 Upregulation of Akt/Raptor signaling is associated with rapamycin resistance of breast cancer cells. 2020 Oct 1 1
95 32911743 Metformin Suppresses Cancer Stem Cells through AMPK Activation and Inhibition of Protein Prenylation of the Mevalonate Pathway in Colorectal Cancer. 2020 Sep 8 1
96 32934724 Therapeutic effect of metformin in the treatment of endometrial cancer. 2020 Nov 1
97 32943543 Synthetic Lethal Metabolic Targeting of Androgen-Deprived Prostate Cancer Cells with Metformin. 2020 Nov 1
98 32945402 Metformin promotes cell proliferation and osteogenesis under high glucose condition by regulating the ROS‑AKT‑mTOR axis. 2020 Oct 5
99 33099954 Metformin induces apoptosis of melanoma B16 cells via PI3K/Akt/mTOR signaling pathways. 2020 Jul-Aug 2
100 33116117 Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma. 2020 Oct 28 1