Title : SLCO1B1 polymorphism is not associated with risk of statin-induced myalgia/myopathy in a Czech population.

Pub. Date : 2015 May 20

PMID : 25992810






2 Functional Relationships(s)
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1 However, the impact of SLCO1B1 gene polymorphism on this risk in patients treated with other statins or lower doses of simvastatin needs to be assessed. Simvastatin solute carrier organic anion transporter family member 1B1 Homo sapiens
2 MATERIAL/METHODS: SLCO1B1 tagging rs4363657 polymorphism was analyzed in 2 groups of patients with dyslipidemia (treated with simvastatin or atorvastatin, 10 or 20 mg per day), subgroup with statin-induced myalgia (N=286), and subgroup (N=707) without myalgia/myopathy, and in 2301 population controls without lipid-lowering treatment. Simvastatin solute carrier organic anion transporter family member 1B1 Homo sapiens