Pub. Date : 2021 Nov
PMID : 34606062
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To identify whether variations in genes encoding cytochrome P450 (CYP) enzymes or in the SLCO1B1 gene (Solute Carrier Organic anion transporting polypeptide 1B1 gene, encoding the organic anion transporting polypeptide 1B1 (OATP1B1) drug transporter enzyme), and/or characteristics of concomitantly used drugs, predispose patients to simvastatin-associated pulmonary toxicity. | Simvastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | OBJECTIVE: To identify whether variations in genes encoding cytochrome P450 (CYP) enzymes or in the SLCO1B1 gene (Solute Carrier Organic anion transporting polypeptide 1B1 gene, encoding the organic anion transporting polypeptide 1B1 (OATP1B1) drug transporter enzyme), and/or characteristics of concomitantly used drugs, predispose patients to simvastatin-associated pulmonary toxicity. | Simvastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 3 | OBJECTIVE: To identify whether variations in genes encoding cytochrome P450 (CYP) enzymes or in the SLCO1B1 gene (Solute Carrier Organic anion transporting polypeptide 1B1 gene, encoding the organic anion transporting polypeptide 1B1 (OATP1B1) drug transporter enzyme), and/or characteristics of concomitantly used drugs, predispose patients to simvastatin-associated pulmonary toxicity. | Simvastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |