Pub. Date : 2020 Dec 1
PMID : 33270123
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The solute carrier organic anion transporter family member 1B1 (SLCO1B1) genotype is associated with simvastatin myopathy risk and is proposed for clinical implementation. | Simvastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | The solute carrier organic anion transporter family member 1B1 (SLCO1B1) genotype is associated with simvastatin myopathy risk and is proposed for clinical implementation. | Simvastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 3 | Overall, 120 participants (29%) had a SLCO1B1 genotype indicating increased simvastatin myopathy risk. | Simvastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 4 | Among patients with a decreased or poor SLCO1B1 transporter function genotype, simvastatin was prescribed to 1 patient in the control group but none in the intervention group. | Simvastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 5 | Conclusions and Relevance: Clinical testing and reporting of SLCO1B1 results for statin myopathy risk did not result in poorer ASCVD prevention in a routine primary care setting and may have been associated with physicians avoiding simvastatin prescriptions for patients at genetic risk for SAMS. | Simvastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |