| 1 |
35012873 | Structural advances in sterol-sensing domain-containing proteins. | 2022 Apr |
1 |
| 2 |
33177619 | Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation. | 2021 Apr |
2 |
| 3 |
33907281 | Phagocytic and pinocytic uptake of cholesterol in Tetrahymena thermophila impact differently on gene regulation for sterol homeostasis. | 2021 Apr 27 |
1 |
| 4 |
31919352 | Structural basis for itraconazole-mediated NPC1 inhibition. | 2020 Jan 9 |
1 |
| 5 |
33021976 | Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain. | 2020 Oct |
1 |
| 6 |
30942586 | Computational Tools Unravel Putative Sterol Binding Sites in the Lysosomal NPC1 Protein. | 2019 May 28 |
1 |
| 7 |
31543266 | Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins. | 2019 Oct 3 |
7 |
| 8 |
31867479 | Computational Modeling Explains the Multi Sterol Ligand Specificity of the N-Terminal Domain of Niemann-Pick C1-Like 1 Protein. | 2019 Dec 17 |
1 |
| 9 |
28988886 | The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1. | 2018 Jan |
1 |
| 10 |
30054450 | Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. | 2018 Oct 1 |
1 |
| 11 |
30123067 | Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking. | 2018 |
2 |
| 12 |
27994139 | Triazoles inhibit cholesterol export from lysosomes by binding to NPC1. | 2017 Jan 3 |
1 |
| 13 |
28103683 | Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis. | 2017 Jan 20 |
1 |
| 14 |
28465104 | Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein. | 2017 Jun 15 |
2 |
| 15 |
28564600 | Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System. | 2017 May 30 |
1 |
| 16 |
27238017 | Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. | 2016 Jun 2 |
1 |
| 17 |
27307437 | Structure of human Niemann-Pick C1 protein. | 2016 Jul 19 |
1 |
| 18 |
27421092 | Role of STARD4 and NPC1 in intracellular sterol transport. | 2016 Dec |
1 |
| 19 |
25285302 | The Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments. | 2014 Feb 28 |
2 |
| 20 |
23521797 | Discovery of oxysterol-derived pharmacological chaperones for NPC1: implication for the existence of second sterol-binding site. | 2013 Mar 21 |
4 |
| 21 |
24131821 | Defining structural and evolutionary modules in proteins: a community detection approach to explore sub-domain architecture. | 2013 Oct 16 |
2 |
| 22 |
24180231 | Synthesis of 2-hydroxypropyl-β-cyclodextrin/pluronic-based polyrotaxanes via heterogeneous reaction as potential Niemann-Pick type C therapeutics. | 2013 Dec 9 |
2 |
| 23 |
22117698 | Proteins that bind and move lipids: MsbA and NPC1. | 2012 Jan-Feb |
1 |
| 24 |
21525977 | The structure of the NPC1L1 N-terminal domain in a closed conformation. | 2011 Apr 15 |
1 |
| 25 |
21550990 | Altered vitamin E status in Niemann-Pick type C disease. | 2011 Jul |
1 |
| 26 |
22174676 | Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity. | 2011 Dec |
1 |
| 27 |
19029290 | Characterization of fluorescent sterol binding to purified human NPC1. | 2009 Jan 16 |
2 |
| 28 |
19122238 | Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden Syrian hamster. | 2009 Jun |
1 |
| 29 |
19416638 | Mechanisms and consequences of impaired lipid trafficking in Niemann-Pick type C1-deficient mammalian cells. | 2009 Jul |
1 |
| 30 |
19583955 | Identification of cholesterol-regulating genes by targeted RNAi screening. | 2009 Jul |
2 |
| 31 |
18272927 | The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts. | 2008 May |
2 |
| 32 |
18272928 | Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues. | 2008 May |
2 |
| 33 |
18445594 | Plasma membrane cholesterol content affects nitric oxide diffusion dynamics and signaling. | 2008 Jul 4 |
2 |
| 34 |
16757520 | Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4. | 2006 Jul 1 |
1 |
| 35 |
16876994 | Nonvesicular sterol transport: two protein families and a sterol sensor? | 2006 Sep |
1 |
| 36 |
15908696 | The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol. | 2005 Aug 5 |
6 |
| 37 |
15030792 | The niemann-pick disease genes; regulators of cellular cholesterol homeostasis. | 2004 Feb |
1 |
| 38 |
15314240 | Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. | 2004 Aug 24 |
1 |
| 39 |
15347664 | Targeting of NPC1 to late endosomes involves multiple signals, including one residing within the putative sterol-sensing domain. | 2004 Nov 12 |
1 |
| 40 |
15465429 | The pathophysiology and mechanisms of NP-C disease. | 2004 Oct 11 |
2 |
| 41 |
12719428 | NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. | 2003 Jul 11 |
1 |
| 42 |
12398991 | Sterols and intracellular vesicular trafficking: lessons from the study of NPC1. | 2002 Nov |
1 |
| 43 |
11032830 | Sterol-modulated glycolipid sorting occurs in niemann-pick C1 late endosomes. | 2001 Feb 2 |
1 |
| 44 |
11333381 | Niemann-Pick C1 disease: correlations between NPC1 mutations, levels of NPC1 protein, and phenotypes emphasize the functional significance of the putative sterol-sensing domain and of the cysteine-rich luminal loop. | 2001 Jun |
1 |
| 45 |
10783261 | Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1. | 2000 Apr 15 |
1 |
| 46 |
10801441 | A model for niemann-pick type C disease in the nematode Caenorhabditis elegans. | 2000 May 4 |
2 |
| 47 |
10964915 | Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis. | 2000 Dec 8 |
2 |
| 48 |
11001808 | The structure and function of the Niemann-Pick C1 protein. | 2000 Sep-Oct |
1 |
| 49 |
10092649 | The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo. | 1999 Apr 2 |
4 |
| 50 |
10227680 | Lipid changes in Niemann-Pick disease type C brain: personal experience and review of the literature. | 1999 Apr |
2 |