Title : Targeting of NPC1 to late endosomes involves multiple signals, including one residing within the putative sterol-sensing domain.

Pub. Date : 2004 Nov 12

PMID : 15347664






1 Functional Relationships(s)
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1 By using various FLAG-tagged and CD32-NPC1 chimeric fusion constructs, we show that multiple signals are responsible for the trafficking of NPC1 to the endosomal compartment, including the dileucine motif and a previously unidentified signal residing within the putative sterol-sensing domain transmembrane domain 3. Sterols NPC intracellular cholesterol transporter 1 Homo sapiens