Pub. Date : 1999 Apr 2
PMID : 10092649
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Drugs that block sterol transport out of lysosomes also redistribute NPC1 to cholesterol-laden lysosomes. | Sterols | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | These findings suggest that NPC1(+) vesicles may transiently interact with lysosomes to facilitate sterol relocation. | Sterols | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 3 | Low density lipoprotein uptake by normal cells retards retrograde transport of [14C]sucrose through this same kinetic compartment, further suggesting that it may contain the sterol-sensing NPC1 protein. | Sterols | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 4 | We conclude that a distinctive organelle containing NPC1 mediates retrograde lysosomal transport of endocytosed cargo that is not restricted to sterol. | Sterols | NPC intracellular cholesterol transporter 1 | Homo sapiens |