Title : Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection.

Pub. Date : 2016 Jun 2

PMID : 27238017






1 Functional Relationships(s)
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Protein Name
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1 NPC1 contains 13 transmembrane segments (TMs) and three distinct lumenal domains A (also designated NTD), C, and I. TMs 2-13 exhibit a typical resistance-nodulation-cell division fold, among which TMs 3-7 constitute the sterol-sensing domain conserved in several proteins involved in cholesterol metabolism and signaling. Sterols NPC intracellular cholesterol transporter 1 Homo sapiens