| 1 |
35129766 | The edited UPF1 is correlated with elevated asparagine synthetase in pancreatic ductal adenocarcinomas. | 2022 May |
2 |
| 2 |
35205650 | Novel Insights on the Use of L-Asparaginase as an Efficient and Safe Anti-Cancer Therapy. | 2022 Feb 11 |
2 |
| 3 |
35208238 | Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort Study. | 2022 Feb 9 |
4 |
| 4 |
33615182 | Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms. | 2021 Feb 12 |
3 |
| 5 |
33777794 | Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma. | 2021 |
3 |
| 6 |
33822775 | Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation. | 2021 May 10 |
6 |
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34267184 | Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells. | 2021 Jul 15 |
2 |
| 8 |
31421261 | Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling. | 2020 |
1 |
| 9 |
32268116 | ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase. | 2020 Apr 7 |
1 |
| 10 |
32273511 | p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. | 2020 Apr 9 |
3 |
| 11 |
32800652 | The role of asparagine synthetase on nutrient metabolism in pancreatic disease. | 2020 Sep |
3 |
| 12 |
33167336 | Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability. | 2020 Nov 5 |
1 |
| 13 |
30858360 | SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis. | 2019 Mar 11 |
1 |
| 14 |
31123592 | Clinical outcomes of two patients with a novel pathogenic variant in ASNS: response to asparagine supplementation and review of the literature. | 2019 |
2 |
| 15 |
31594813 | Asparagine Deprivation Causes a Reversible Inhibition of Human Cytomegalovirus Acute Virus Replication. | 2019 Oct 8 |
1 |
| 16 |
31659118 | Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. | 2019 Dec 6 |
3 |
| 17 |
28842428 | Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis. | 2018 Jan |
3 |
| 18 |
29956571 | Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis. | 2018 |
1 |
| 19 |
30480096 | Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways. | 2018 |
2 |
| 20 |
28659375 | Role of glutamine and interlinked asparagine metabolism in vessel formation. | 2017 Aug 15 |
3 |
| 21 |
29084849 | Asparagine synthetase: Function, structure, and role in disease. | 2017 Dec 8 |
2 |
| 22 |
29299118 | Identification of a cytogenetic and molecular subgroup of acute myeloid leukemias showing sensitivity to L-Asparaginase. | 2017 Dec 15 |
2 |
| 23 |
25858017 | Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells. | 2016 May |
2 |
| 24 |
27251594 | Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells. | 2016 Oct |
2 |
| 25 |
27764698 | Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase. | 2016 Nov |
3 |
| 26 |
25626693 | Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines. | 2015 Jan 28 |
2 |
| 27 |
25663424 | Asparagine Synthetase Deficiency: New Inborn Errors of Metabolism. | 2015 |
1 |
| 28 |
26318253 | Asparagine Synthetase Deficiency causes reduced proliferation of cells under conditions of limited asparagine. | 2015 Nov |
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| 29 |
26499495 | Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma. | 2015 Oct 24 |
2 |
| 30 |
24474640 | Expression levels of ASNS in mesenchymal stromal cells in childhood acute lymphoblastic leukemia. | 2014 Mar |
1 |
| 31 |
24505127 | Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors. | 2014 May |
1 |
| 32 |
23403946 | Asparagine synthetase: regulation by cell stress and involvement in tumor biology. | 2013 Apr 15 |
2 |
| 33 |
24139043 | Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy. | 2013 Oct 16 |
1 |
| 34 |
22245216 | Integrative molecular profiling reveals asparagine synthetase is a target in castration-resistant prostate cancer. | 2012 Mar |
2 |
| 35 |
22513289 | Pancreatic tumor sensitivity to plasma L-asparagine starvation. | 2012 Aug |
1 |
| 36 |
22542578 | Low expression of asparagine synthetase in lymphoid blasts precludes its role in sensitivity to L-asparaginase. | 2012 Aug |
1 |
| 37 |
22951255 | A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells. | 2012 Oct 1 |
1 |
| 38 |
21972289 | ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia. | 2011 Nov 24 |
1 |
| 39 |
20561401 | [Relationship between asparagine synthetase expression level and cell sensitivity to L-asparaginase in human leukemic cell lines]. | 2010 Jun |
1 |
| 40 |
18541474 | Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients. | 2008 Apr 30 |
1 |
| 41 |
17380207 | Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. | 2007 Apr |
2 |
| 42 |
15385533 | Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation. | 2004 Dec 3 |
1 |
| 43 |
2569668 | Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase. | 1989 Jun |
1 |