Pub. Date : 2019 Dec 6
PMID : 31659118
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | For example, during amino acid limitations, ATF4 in the amino acid response induces expression of asparagine synthetase (ASNS), which provides for asparagine biosynthesis. | Asparagine | asparagine synthetase (glutamine-hydrolyzing) | Homo sapiens |
| 2 | Here we show that DNA hypermethylation at the ASNS promoter prevents its transcriptional expression following asparagine depletion. | Asparagine | asparagine synthetase (glutamine-hydrolyzing) | Homo sapiens |
| 3 | We conclude that chromatin accessibility is critical for ATF4 activity at the ASNS promoter, which can switch ALL cells from an ATF4-dependent adaptive response to ATF4-independent apoptosis during asparagine depletion. | Asparagine | asparagine synthetase (glutamine-hydrolyzing) | Homo sapiens |