Title : Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma.

Pub. Date : 2015 Oct 24

PMID : 26499495






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Also, asparagine depletion via the ASNS inhibitor amino sulfoximine 5 (AS5) or asparaginase inhibited mouse and human sarcoma growth in vitro, and genetic silencing of ASNS in mouse sarcoma cells combined with depletion of plasma asparagine inhibited tumor growth in vivo. Asparagine asparagine synthetase (glutamine-hydrolyzing) Homo sapiens
2 Also, asparagine depletion via the ASNS inhibitor amino sulfoximine 5 (AS5) or asparaginase inhibited mouse and human sarcoma growth in vitro, and genetic silencing of ASNS in mouse sarcoma cells combined with depletion of plasma asparagine inhibited tumor growth in vivo. Asparagine asparagine synthetase (glutamine-hydrolyzing) Homo sapiens