Title : Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability.

Pub. Date : 2020 Nov 5

PMID : 33167336






1 Functional Relationships(s)
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1 Osteoblastogenesis also triggers the induction of glutamine-dependent asparagine synthetase (ASNS), and, among non-essential amino acids, asparagine rescues differentiation of glutamine-starved MSCs, by restoring the transcriptional profiles of differentiating MSCs altered by glutamine starvation. Asparagine asparagine synthetase (glutamine-hydrolyzing) Homo sapiens