Aphidicolin

DNA polymerase alpha 1, catalytic subunit ; Homo sapiens







138 Article(s)
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1 31026293 DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA. 2019 Apr 1
2 31403790 Aphidicolin Chemistry of the Deep-Sea-Derived Fungus Botryotinia fuckeliana MCCC 3A00494. 2019 Aug 23 1
3 25429975 Structural basis for inhibition of DNA replication by aphidicolin. 2014 Dec 16 4
4 19269999 Penta-O-galloyl-beta-D-glucose induces S- and G(1)-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1. 2009 May 1
5 18341260 Targeting human DNA polymerase alpha for the inhibition of keratinocyte proliferation. Part 1. Homology model, active site architecture and ligand binding. 2008 Feb 1
6 18616816 Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis. 2008 Jul 10 1
7 14603443 The role of late/slow replication of the FRA16D in common fragile site induction. 2004 Jan 1
8 15309689 Chromosomal instability at common fragile sites in Seckel syndrome. 2004 Oct 1
9 12688717 Diastereoselective formal total synthesis of the DNA polymerase alpha inhibitor, aphidicolin, using palladium-catalyzed cycloalkenylation and intramolecular Diels-Alder reactions. 2003 Apr 17 1
10 11827715 Aphidicolin induces 6-thioguanine resistant mutants in human diploid fibroblasts. 2002 Feb 20 1
11 11891323 Quantitative measurement of translesion replication in human cells: evidence for bypass of abasic sites by a replicative DNA polymerase. 2002 Mar 19 1
12 12149019 Proposed mechanism for the reaction catalyzed by a diterpene cyclase, aphidicolan-16beta-ol synthase: experimental results on biomimetic cyclization and examination of the cyclization pathway by ab initio calculations. 2002 Aug 7 1
13 12459445 Efficiency, specificity and DNA polymerase-dependence of translesion replication across the oxidative DNA lesion 8-oxoguanine in human cells. 2002 Dec 29 1
14 10342290 Antisense oligonucleotide complementary to the BamHI-H gene family of Marek's disease virus induced growth arrest of MDCC-MSB1 cells in the S-phase. 1999 Apr 1
15 9499431 Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction. 1998 Apr 1
16 9530343 Reduced DNA repair capacity in breast cancer patients and unaffected individuals from breast cancer families. 1998 Apr 1 1
17 9637237 Repair of DNA damage in mammalian cells after treatment with UV and dimethyl sulphate: discrimination between nucleotide and base excision repair by their temperature dependence. 1998 Mar 1
18 9802062 Replication-dependent and -independent camptothecin cytotoxicity of seven human colon tumor cell lines. 1998 1
19 9057979 DNA single-strand breaks in L-132 cells resulting from inhibition of repair polymerization shortly after exposure to dimethylarsinic acid. 1997 Feb 1
20 9455920 Externalization and binding of galectin-1 on cell surface of K562 cells upon erythroid differentiation. 1997 Dec 1
21 8646799 Nucleotide excision repair in the human ovarian carcinoma cell line (2008) and its cisplatin-resistant variant (C13*). 1996 1
22 8800198 Fluorodeoxyuridine-mediated cytotoxicity and radiosensitization require S phase progression. 1996 Sep 1
23 8813556 Cross-resistance to cis-diamminedichloroplatinum(II) of a multidrug-resistant lymphoma cell line associated with decreased drug accumulation and enhanced DNA repair. 1996 Jun 3 1
24 8825452 Detection and characterization of DNA polymerase activity in Entamoeba histolytica. 1996 2
25 8840989 DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells. 1996 Oct 15 1
26 8860956 Dimethylarsenics reveal DNA damage induced by superoxide anion radicals. 1996 Apr 1
27 8871556 Characterization of the DNA polymerase requirement of human base excision repair. 1996 Oct 1 1
28 7529174 Productive HIV-1 infection of macrophages restricted to the cell fraction with proliferative capacity. 1994 Dec 15 1
29 7805758 Enhanced excision repair of DNA damage due to cis-diamminedichloroplatinum(II) in resistant cervix carcinoma HeLa cells. 1994 Aug 16 1
30 7918625 Involvement of DNA polymerase delta and/or epsilon in joining UV-induced DNA single strand breaks in human fibroblasts (comparison of effects of butylphenyldeoxyguanosine with aphidicolin). 1994 Oct 18 1
31 8137287 Interaction of ionizing radiation with the topoisomerase I poison camptothecin in growing V-79 and HeLa cells. 1994 Apr 1 1
32 8267640 Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in human myeloid leukemia cell lines. 1993 Dec 3 1
33 1315927 Dideoxynucleoside triphosphates inhibit a late stage of SV40 DNA replication in vitro. 1992 Mar 4 1
34 1483268 Aphidicolin selectively kills neuroblastoma cells in vitro. 1992 Dec 24 1
35 1573280 DNA synthesis in nuclei isolated from Daudi B cells: a model to study the antiproliferative mechanisms of interferon-alpha. 1992 Feb 1
36 1576158 Isolation and partial characterization of a high-molecular-weight DNA polymerase from Leishmania mexicana. 1992 Apr 17 1
37 1657184 Plasmids bearing mammalian DNA-replication origin-enriched (ors) fragments initiate semiconservative replication in a cell-free system. 1991 Oct 8 1
38 1706219 Inhibition of primer RNA formation in CCRF-CEM leukemia cells by fludarabine triphosphate. 1991 Apr 1 2
39 1709825 Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes. 1991 Jul 1
40 1742484 Aphidicolin, an inhibitor of DNA replication, blocks the TPA-induced differentiation of a human megakaryoblastic cell line, MEG-O1. 1991 Dec 15 1
41 1753100 Dependence of cell survival on DNA repair in human mononuclear phagocytes. 1991 Dec 15 2
42 1900132 Mutants from V79 fibroblasts exhibiting hypersensitivity to aphidicolin and 3'-azido-3'-deoxythymidine. 1991 Jan 1
43 1900227 A new class of reversible cell cycle inhibitors. 1991 1
44 1903085 On the association of DNA polymerase alpha activity with the nuclear matrix in HeLa cells. 1991 Feb 1
45 1903691 Mimosine reversibly arrests cell cycle progression at the G1-S phase border. 1991 1
46 1905143 DNA polymerase delta mediates excision repair in growing cells damaged with ultraviolet radiation. 1991 Apr 1
47 1905189 DNA single stranded gaps formed during DNA repair synthesis induced by methyl methanesulfonate are filled by sequential action of aphidicolin- and dideoxythymidine sensitive DNA polymerases in HeLa cells. 1991 Jan 1
48 1905242 Cell cycle-dependent biosynthesis of Plasmodium falciparum DNA polymerase-alpha. 1991 Jul 1
49 1944347 DNA polymerase delta mediates increase in exchange production by X-radiation in human lymphocytes moving from G0 to G1. 1991 Sep-Oct 1
50 1995629 Heteroduplex repair in extracts of human HeLa cells. 1991 Feb 25 1