Title : Chromosomal instability at common fragile sites in Seckel syndrome.

Pub. Date : 2004 Oct

PMID : 15309689






1 Functional Relationships(s)
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1 We found that, compared with controls, there is greater chromosomal instability, particularly at fragile sites, in SCKL1-affected patient cells after treatment with aphidicolin, an inhibitor of DNA polymerase alpha and other polymerases. Aphidicolin DNA polymerase alpha 1, catalytic subunit Homo sapiens