Pub. Date : 2014 Dec 16
PMID : 25429975
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we report the crystal structure of the catalytic core of human DNA polymerase alpha (Pol alpha) in the ternary complex with an RNA-primed DNA template and aphidicolin. | Aphidicolin | DNA polymerase alpha 1, catalytic subunit | Homo sapiens |
| 2 | Here we report the crystal structure of the catalytic core of human DNA polymerase alpha (Pol alpha) in the ternary complex with an RNA-primed DNA template and aphidicolin. | Aphidicolin | DNA polymerase alpha 1, catalytic subunit | Homo sapiens |
| 3 | The structure provides a plausible mechanism for the selectivity of aphidicolin incorporation opposite template guanine and explains why previous modifications of aphidicolin failed to improve its affinity for Pol alpha. | Aphidicolin | DNA polymerase alpha 1, catalytic subunit | Homo sapiens |
| 4 | The structure provides a plausible mechanism for the selectivity of aphidicolin incorporation opposite template guanine and explains why previous modifications of aphidicolin failed to improve its affinity for Pol alpha. | Aphidicolin | DNA polymerase alpha 1, catalytic subunit | Homo sapiens |