PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1573280-2 1992 [3H]dTTP incorporation in isolated nuclei was shown to be representative of replicative DNA synthesis by evidence that (i) incorporation was dependent on ATP and all four nucleoside precursors, (ii) incorporation was inhibited greater than 97% by aphidicolin, a specific inhibitor of DNA polymerase alpha and delta, and (iii) the DNase I-sensitive product banded in neutral CsCl at a density indicative of replicative DNA. Aphidicolin 247-258 DNA polymerase alpha 1, catalytic subunit Homo sapiens 284-304 1483268-1 1992 Aphidicolin is a tetracyclic diterpene antibiotic which is known to inhibit the growth of eucaryotic cells by reversible binding to DNA polymerase alpha without significant effect on cell viability in most common human cell lines. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 132-152 1576158-3 1992 Unlike mammalian DNA polymerase alpha, but similar to the predominant DNA polymerase isolated from the related lower eukaryotic organisms, Trypanosoma cruzi and Crithidia fasciculata, the leishmanial DNA polymerase A is resistant to inhibition by aphidicolin, a potent inhibitor of DNA replication in mammalian cells and of DNA polymerase alpha. Aphidicolin 247-258 DNA polymerase alpha 1, catalytic subunit Homo sapiens 200-216 1315927-2 1992 Inhibition of DNA polymerase alpha by addition of aphidicolin or monoclonal antibodies prevented DNA synthesis, confirming the requirement for this enzyme in replication. Aphidicolin 50-61 DNA polymerase alpha 1, catalytic subunit Homo sapiens 14-34 1742484-9 1991 Aphidicolin, a specific inhibitor of DNA polymerase alpha, completely inhibited the differentiation induction of MEG-O1 cells with TPA measured by either GP IIb/IIIa expression or multinuclear cell formation. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 37-57 1753100-7 1991 DNA repair synthesis in normal monocytes is blocked by aphidicolin, an inhibitor of DNA polymerase-alpha with respect to dCTP. Aphidicolin 55-66 DNA polymerase alpha 1, catalytic subunit Homo sapiens 84-104 1753100-12 1991 The unexpected toxicity of aphidicolin toward normal human monocytes may be attributable to their high rate of spontaneous DNA strand break formation, to the importance of DNA polymerase-alpha for DNA repair in these cells, and to their minute dCTP pools. Aphidicolin 27-38 DNA polymerase alpha 1, catalytic subunit Homo sapiens 172-192 1657184-10 1991 Replication of the ors plasmids was not inhibited by ddTTP, an inhibitor of DNA polymerase beta and gamma, and was sensitive to aphidicolin indicating that DNA polymerase alpha and/or delta was responsible for DNA synthesis. Aphidicolin 128-139 DNA polymerase alpha 1, catalytic subunit Homo sapiens 156-176 1903085-3 1991 Typically over 98% of the total DNA synthesized in the matrix fraction on either endogenous matrix-associated DNA or activated calf thymus DNA was due to DNA polymerase alpha as defined by inhibition to n-ethylmaleimide or aphidicolin. Aphidicolin 223-234 DNA polymerase alpha 1, catalytic subunit Homo sapiens 154-174 1944347-2 1991 Post-treatment of lymphocytes irradiated in G0 with the DNA polymerase inhibitor aphidicolin, which is effective against both pol alpha and pol delta, produces a similar increase in ring and dicentric yield. Aphidicolin 81-92 DNA polymerase alpha 1, catalytic subunit Homo sapiens 126-135 1905242-1 1991 The DNA polymerase-alpha of Plasmodium falciparum was characterized according to aphidicolin sensitivity and immunological reactivity with monoclonal anti-sera against human DNA polymerase-alpha. Aphidicolin 81-92 DNA polymerase alpha 1, catalytic subunit Homo sapiens 4-24 1905143-2 1991 The sensitivity of repair synthesis to aphidicolin, an inhibitor of DNA polymerases alpha and delta, was determined in growth phase and confluent normal human fibroblasts (AG1518) using several techniques. Aphidicolin 39-50 DNA polymerase alpha 1, catalytic subunit Homo sapiens 68-89 1995629-10 1991 Aphidicolin, an inhibitor of DNA polymerases alpha, delta, and epsilom, inhibits both semiconservative replication and repair synthesis in the extract. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 29-50 1709825-7 1991 However, aphidicolin, an inhibitor of DNA polymerase alpha inhibited cell proliferation to the same extent as pentoxifylline, but had no effect on IL-2R expression, indicating that inhibition of cell proliferation does not necessarily lead to inhibition of IL-2R expression. Aphidicolin 9-20 DNA polymerase alpha 1, catalytic subunit Homo sapiens 38-58 1706219-9 1991 The effects of ara-CTP and aphidicolin on these enzymes were opposite those seen with Fara-ATP, since 50% inhibitory concentrations of either ara-CTP or aphidicolin for DNA polymerases alpha/delta did not inhibit polydeoxythymidylate primase activity. Aphidicolin 27-38 DNA polymerase alpha 1, catalytic subunit Homo sapiens 169-190 1706219-9 1991 The effects of ara-CTP and aphidicolin on these enzymes were opposite those seen with Fara-ATP, since 50% inhibitory concentrations of either ara-CTP or aphidicolin for DNA polymerases alpha/delta did not inhibit polydeoxythymidylate primase activity. Aphidicolin 153-164 DNA polymerase alpha 1, catalytic subunit Homo sapiens 169-190 1905189-1 1991 DNA repair synthesis induced by methyl methanesulfonate in preconditioned HeLa cells in which DNA replicative synthesis had been highly suppressed was inhibited by aphidicolin (an inhibitor of DNA polymerases alpha and delta) and dideoxythymidine (ddThR, an inhibitor of DNA polymerase beta). Aphidicolin 164-175 DNA polymerase alpha 1, catalytic subunit Homo sapiens 193-224 1900227-2 1991 Ciclopirox olamine, an antifungal agent, and the compound Hoechst 768159 reversibly block the cell cycle at a point occurring roughly 1 h before the arrest mediated by aphidicolin, an inhibitor of DNA polymerase alpha activity, which acts in early S phase. Aphidicolin 168-179 DNA polymerase alpha 1, catalytic subunit Homo sapiens 197-217 1903691-2 1991 These results were obtained by using flow cytometric analysis of DNA content to compare the effects of mimosine on cell cycle traverse with those of aphidicolin, an inhibitor of DNA polymerase alpha activity. Aphidicolin 149-160 DNA polymerase alpha 1, catalytic subunit Homo sapiens 178-198 2121512-1 1990 To analyze the relationship between differentiation and DNA replication, the effect of aphidicolin, a specific inhibitor for DNA polymerase alpha, was measured with respect to erythroid differentiation and activities of DNA polymerases alpha, beta, and gamma. Aphidicolin 87-98 DNA polymerase alpha 1, catalytic subunit Homo sapiens 125-145 1900132-1 1991 One variant, aphhs-3 was previously isolated based on a hypersensitivity to nontoxic concentrations of aphidicolin, a specific inhibitor of DNA polymerases-alpha and delta. Aphidicolin 103-114 DNA polymerase alpha 1, catalytic subunit Homo sapiens 140-161 2175436-6 1990 We conclude that DNA polymerase alpha (and/or delta) is required because repair is inhibited by antibodies to human DNA polymerase alpha, as well as by aphidicolin, an inhibitor of polymerases alpha (and/or delta). Aphidicolin 152-163 DNA polymerase alpha 1, catalytic subunit Homo sapiens 17-37 2121512-1 1990 To analyze the relationship between differentiation and DNA replication, the effect of aphidicolin, a specific inhibitor for DNA polymerase alpha, was measured with respect to erythroid differentiation and activities of DNA polymerases alpha, beta, and gamma. Aphidicolin 87-98 DNA polymerase alpha 1, catalytic subunit Homo sapiens 220-241 2121512-4 1990 The enzyme activity of DNA polymerase alpha of K562 cells showed a 50-110% increase with aphidicolin treatment as compared to control K562 cells; activities of DNA polymerases beta and gamma were not affected. Aphidicolin 89-100 DNA polymerase alpha 1, catalytic subunit Homo sapiens 23-43 2121512-6 1990 The enzyme activity of DNA polymerase alpha remained high even after removal of aphidicolin from the culture medium. Aphidicolin 80-91 DNA polymerase alpha 1, catalytic subunit Homo sapiens 23-43 2122528-4 1990 Partially purified DNA polymerase alpha from AC3, but not from AC1 or AC2, showed resistance to aphidicolin. Aphidicolin 96-107 DNA polymerase alpha 1, catalytic subunit Homo sapiens 19-39 2122528-10 1990 These results show that in mammalian cells there are at least two mechanisms of aphidicolin-resistance that involve an altered DNA polymerase alpha that is resistant to aphidicolin and simultaneous expansion of the four DNA-precursor pools. Aphidicolin 80-91 DNA polymerase alpha 1, catalytic subunit Homo sapiens 127-147 2122528-10 1990 These results show that in mammalian cells there are at least two mechanisms of aphidicolin-resistance that involve an altered DNA polymerase alpha that is resistant to aphidicolin and simultaneous expansion of the four DNA-precursor pools. Aphidicolin 169-180 DNA polymerase alpha 1, catalytic subunit Homo sapiens 127-147 1694964-2 1990 Incubation of irradiated cells with aphidicolin, an inhibitor of DNA polymerases alpha and delta, delayed the sealing of repair patches and allowed estimation of rates of strand incision by the repair endonuclease. Aphidicolin 36-47 DNA polymerase alpha 1, catalytic subunit Homo sapiens 65-86 2116798-4 1990 Addition of aphidicolin, an inhibitor for DNA polymerase alpha, to resistant cells effectively blocked enhanced plasmid reactivation and acquired resistance. Aphidicolin 12-23 DNA polymerase alpha 1, catalytic subunit Homo sapiens 42-62 2117783-2 1990 DNA repair synthesis and excision were inhibited by aphidicolin, a specific inhibitor of DNA polymerase-alpha. Aphidicolin 52-63 DNA polymerase alpha 1, catalytic subunit Homo sapiens 89-109 1702366-4 1990 Furthermore, the inhibition by HO-221 of DNA polymerase alpha was found to be non-competitive with respect to dCTP as a substrate, unlike that induced by aphidicolin and ara-CTP. Aphidicolin 154-165 DNA polymerase alpha 1, catalytic subunit Homo sapiens 41-61 2153561-2 1990 Mimosine, a plant amino acid, reversibly blocks the cell cycle at a point which occurs roughly 2 h before the arrest mediated by aphidicolin, an inhibitor of DNA polymerase alpha activity, which defines the G1/S phase boundary. Aphidicolin 129-140 DNA polymerase alpha 1, catalytic subunit Homo sapiens 158-178 1689958-6 1990 When aphidicolin was used to inhibit repair mediated by DNA polymerase alpha, both normal control and Fanconi anemia fibroblasts showed significantly more chromosome breakage than was produced by bleomycin alone, but there was no increase in the amount of breakage seen in the N syndrome fibroblasts over that seen with bleomycin alone. Aphidicolin 5-16 DNA polymerase alpha 1, catalytic subunit Homo sapiens 56-76 2480788-3 1989 Under identical conditions, this compound was 60-fold more potent than aphidicolin as an inhibitor of DNA polymerase alpha. Aphidicolin 71-82 DNA polymerase alpha 1, catalytic subunit Homo sapiens 102-122 2482074-1 1989 Treatment of permeable human fibroblasts with bleomycin elicits DNA repair synthesis that is only partially sensitive to aphidicolin, an inhibitor of mammalian DNA polymerases alpha and delta. Aphidicolin 121-132 DNA polymerase alpha 1, catalytic subunit Homo sapiens 160-181 2480115-1 1989 Bleomycin-induced DNA repair synthesis in the permeabilized HeLa cells was sensitive to aphidicolin, an inhibitor of DNA polymerase alpha and delta, and to dideoxythymidine triphosphate (ddTTP), a specific inhibitor of DNA polymerase beta. Aphidicolin 88-99 DNA polymerase alpha 1, catalytic subunit Homo sapiens 117-137 2528644-7 1989 The inhibitor of DNA polymerases alpha and delta, aphidicolin, blocked the excision reaction. Aphidicolin 50-61 DNA polymerase alpha 1, catalytic subunit Homo sapiens 17-38 2500268-3 1989 In this paper we demonstrate that the inhibitor of DNA polymerases alpha and delta, aphidicolin, blocks the repair of all 4NQO adducts. Aphidicolin 84-95 DNA polymerase alpha 1, catalytic subunit Homo sapiens 51-72 2505232-0 1989 Structure-activity relationships for the inhibition of DNA polymerase alpha by aphidicolin derivatives. Aphidicolin 79-90 DNA polymerase alpha 1, catalytic subunit Homo sapiens 55-75 2505232-1 1989 Aphidicolin and 17 derivatives that have been structurally modified in the A- and D-rings were assessed for their ability to inhibit DNA polymerase alpha. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 133-153 2526176-1 1989 Aphidicolin, a specific and direct inhibitor of eukaryotic DNA polymerase alpha, was used to investigate its impact on immunologic reactions in vitro. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 59-79 2537461-4 1989 The results obtained with aphidicolin (an inhibitor of DNA polymerase alpha) show that the binding of 2-AAF to cellular DNA was significantly higher in samples exposed to this compound. Aphidicolin 26-37 DNA polymerase alpha 1, catalytic subunit Homo sapiens 55-75 2457505-4 1988 Cytosine arabinoside induces an early DNA hypermethylation, which is however reversible and drops to the original level after 24 h. Hydroxyurea induces DNA hypermethylation after a lag period of more than 48 h and the DNA polymerase alpha inhibitor aphidicolin has no effect on the DNA methylation level. Aphidicolin 249-260 DNA polymerase alpha 1, catalytic subunit Homo sapiens 218-238 3139281-4 1988 Aphidicolin, a specific inhibitor of DNA polymerase alpha, showed a dose-dependent capacity to inhibit DNA repair in this system with maximum inhibition of 63% at 4 micrograms/ml. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 37-57 3102267-1 1987 Aphidicolin, a specific and reversible inhibitor of DNA polymerase alpha, was examined as a potential tool to evaluate the relationship between proliferative and differentiative events in Friend erythroleukemia cell (FELC) maturation. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 52-72 3126811-3 1988 In normally growing cells we did not observe single-stranded DNA whereas large amounts were present in cells treated with aphidicolin (an inhibitor of DNA polymerase alpha). Aphidicolin 122-133 DNA polymerase alpha 1, catalytic subunit Homo sapiens 151-171 3146346-5 1988 Late UV-induced DNA repair synthesis in both intact and permeable cells was found to be inhibited by aphidicolin, indicating the involvement of one of the aphidicolin-sensitive DNA polymerases, alpha or delta. Aphidicolin 101-112 DNA polymerase alpha 1, catalytic subunit Homo sapiens 177-208 3133639-0 1988 Inhibition of DNA polymerase alpha by aphidicolin derivatives. Aphidicolin 38-49 DNA polymerase alpha 1, catalytic subunit Homo sapiens 14-34 3116599-2 1987 The role of hyperthermic inactivation of DNA polymerase alpha was investigated using the specific DNA polymerase alpha inhibitor, aphidicolin. Aphidicolin 130-141 DNA polymerase alpha 1, catalytic subunit Homo sapiens 98-118 3111741-5 1987 DNA polymerase alpha is involved in the repair of 4NQO-induced lesions because aphidicolin blocks their repair. Aphidicolin 79-90 DNA polymerase alpha 1, catalytic subunit Homo sapiens 0-20 3115608-0 1987 Chemical modification of aphidicolin and the inhibitory effects of its derivatives on DNA polymerase alpha in vitro. Aphidicolin 25-36 DNA polymerase alpha 1, catalytic subunit Homo sapiens 86-106 3098406-5 1987 Aphidicolin is a specific inhibitor of DNA polymerase alpha, the enzyme responsible for the replicative synthesis of DNA. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 39-59 3081804-2 1986 Excision-repair patches in DNA of cells damaged by methyl methanesulfonate were labeled with [3H]thymidine and blocked at an intermediate stage by aphidicolin, an inhibitor of DNA polymerase alpha. Aphidicolin 147-158 DNA polymerase alpha 1, catalytic subunit Homo sapiens 176-196 3085971-2 1986 Excision repair patches in DNA of cells damaged by methyl methanesulfonate were labeled with [3H]thymidine and blocked at an intermediate stage by aphidicolin, an inhibitor of DNA polymerase alpha. Aphidicolin 147-158 DNA polymerase alpha 1, catalytic subunit Homo sapiens 176-196 3084964-6 1986 Given the inhibitory specificity of aphidicolin for DNA polymerase alpha these results provide additional evidence that DNA polymerase alpha plays a role in the excision repair of DNA damaged by UV light or DMS. Aphidicolin 36-47 DNA polymerase alpha 1, catalytic subunit Homo sapiens 52-72 3084964-6 1986 Given the inhibitory specificity of aphidicolin for DNA polymerase alpha these results provide additional evidence that DNA polymerase alpha plays a role in the excision repair of DNA damaged by UV light or DMS. Aphidicolin 36-47 DNA polymerase alpha 1, catalytic subunit Homo sapiens 120-140 3084964-7 1986 It is postulated that aphidicolin interrupts the processivity of the DNA polymerase alpha holoenzyme and allows an exonuclease to enlarge the repair site. Aphidicolin 22-33 DNA polymerase alpha 1, catalytic subunit Homo sapiens 69-89 3786132-7 1986 The purified free DNA primase activity is resistant to neutralizing anti-human DNA polymerase alpha antibodies, BuPdGTP and aphidicolin that specifically inhibit the free DNA polymerase alpha and also DNA polymerase alpha complexed with the primase. Aphidicolin 124-135 DNA polymerase alpha 1, catalytic subunit Homo sapiens 171-191 3786132-7 1986 The purified free DNA primase activity is resistant to neutralizing anti-human DNA polymerase alpha antibodies, BuPdGTP and aphidicolin that specifically inhibit the free DNA polymerase alpha and also DNA polymerase alpha complexed with the primase. Aphidicolin 124-135 DNA polymerase alpha 1, catalytic subunit Homo sapiens 171-191 3463989-3 1986 The immunoreactive protein was purified to homogeneity and identified as a catalytic subunit of DNA polymerase alpha by molecular mass, by aphidicolin sensitivity, and by recognition by a monoclonal antibody against human KB cell DNA polymerase alpha. Aphidicolin 139-150 DNA polymerase alpha 1, catalytic subunit Homo sapiens 96-116 3763398-1 1986 In mammalian cells, both semiconservative DNA replication and the DNA repair patch synthesis induced by high doses of ultraviolet radiation are known to be inhibited by aphidicolin, indicating the involvement in these processes of one or both of the aphidicolin-sensitive DNA polymerases, alpha and/or delta. Aphidicolin 169-180 DNA polymerase alpha 1, catalytic subunit Homo sapiens 272-307 2432831-4 1986 The data suggest a differential DNA repair capacity among human subjects, since aphidicolin is known to inhibit DNA polymerase alpha, which is necessary for DNA replication and DNA repair. Aphidicolin 80-91 DNA polymerase alpha 1, catalytic subunit Homo sapiens 112-132 3759087-7 1986 The simultaneous treatment of lymphocytes with berenil and aphidicolin (inhibitor of DNA polymerase alpha) induces both the rare fra(16)(q22) and the common fra(16)(q23) within the same chromosome. Aphidicolin 59-70 DNA polymerase alpha 1, catalytic subunit Homo sapiens 85-105 2942236-3 1986 The second mechanism is seen in cells treated with aphidicolin, a specific inhibitor of DNA polymerase alpha, to stop the movement of the DNA replication forks. Aphidicolin 51-62 DNA polymerase alpha 1, catalytic subunit Homo sapiens 88-108 3001502-5 1985 Specifically, the enzyme: was sensitive to n-ethylmaleimide and the pol alpha-specific inhibitors, BuPdGTP and aphidicolin; was subject to neutralization by specific monoclonal antibodies raised against human pol alpha; was devoid of detectable 3" to 5" exonuclease activity, and displayed a ribonucleotide-dependent DNA primase activity. Aphidicolin 111-122 DNA polymerase alpha 1, catalytic subunit Homo sapiens 68-77 2417738-7 1986 Studies using the selective inhibitors (aphidicolin, 2",3"-dideoxythymidine 5"-triphosphate and N-ethylmaleimide) for DNA synthesis showed that DNA polymerases alpha and beta were involved in the repair process. Aphidicolin 40-51 DNA polymerase alpha 1, catalytic subunit Homo sapiens 144-165 3936614-3 1985 The DNA polymerase alpha enzyme of the two B-cell lines (both the leukemic and the "normal") showed the usual sensitivity toward inhibition by aphidicolin, while those from the two other leukemic cell lines were remarkably resistant to the antibiotic. Aphidicolin 143-154 DNA polymerase alpha 1, catalytic subunit Homo sapiens 4-24 3001502-5 1985 Specifically, the enzyme: was sensitive to n-ethylmaleimide and the pol alpha-specific inhibitors, BuPdGTP and aphidicolin; was subject to neutralization by specific monoclonal antibodies raised against human pol alpha; was devoid of detectable 3" to 5" exonuclease activity, and displayed a ribonucleotide-dependent DNA primase activity. Aphidicolin 111-122 DNA polymerase alpha 1, catalytic subunit Homo sapiens 209-218 3924406-1 1985 The relationships between replicative DNA synthesis and retinoic acid (RA)-induced differentiation of human promyelocytic leukaemic (HL-60) cells are evaluated with the use of Aphidicolin, a specific and reversible inhibitor of DNA polymerase alpha (alpha). Aphidicolin 176-187 DNA polymerase alpha 1, catalytic subunit Homo sapiens 228-248 3931053-5 1985 The results of the BuAdATP-homopolymer experiments complement those of analogous experiments with BuPdGTP and the dCTP-specific pol alpha inhibitor, aphidicolin, and strengthen the suggestion that mammalian pol alpha contains dNDP and dNTP binding sites which can recognize specific bases without direction by templates. Aphidicolin 149-160 DNA polymerase alpha 1, catalytic subunit Homo sapiens 128-137 3931053-5 1985 The results of the BuAdATP-homopolymer experiments complement those of analogous experiments with BuPdGTP and the dCTP-specific pol alpha inhibitor, aphidicolin, and strengthen the suggestion that mammalian pol alpha contains dNDP and dNTP binding sites which can recognize specific bases without direction by templates. Aphidicolin 149-160 DNA polymerase alpha 1, catalytic subunit Homo sapiens 207-216 3921023-2 1985 Aphidicolin, an inhibitor of DNA polymerase alpha, but not thymidylate synthase, caused a time dependent inhibition of the enzyme when added to the cells after [5-3H]dUrd. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 29-49 3922929-1 1985 The effects of aphidicolin, a specific inhibitor of DNA polymerase alpha, on the repair and fixation of potentially lethal damage (PLD) sensitive to treatment with beta-araA--a drug acting via inhibition of DNA polymerases alpha and beta-have been studied. Aphidicolin 15-26 DNA polymerase alpha 1, catalytic subunit Homo sapiens 52-72 3931652-1 1985 Aphidicolin, a tetracyclic diterpenoid obtained from the culture filtrates of Cephalosporium aphidicola and other fungi, inhibits the growth of eukaryotic cells and of certain animal viruses (SV40, Herpes and Vaccinia viruses) by selectively inhibiting the cellular replicative DNA polymerase alpha or the viral-induced DNA polymerases. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 278-298 3931652-4 1985 Aphidicolin has thus proved extremely useful in elucidating the functional role of DNA polymerase alpha in nuclear DNA replication, of DNA polymerase gamma in mitochondrial DNA synthesis and both DNA polymerases beta and alpha in DNA repair synthesis. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 83-103 2982139-4 1985 In contrast, in cells treated with aphidicolin, which inhibits DNA polymerase alpha, there is continued ligation of 10-kb DNA to high molecular weight DNA. Aphidicolin 35-46 DNA polymerase alpha 1, catalytic subunit Homo sapiens 63-83 6438087-1 1984 In nongrowing mammalian cells, DNA repair synthesis following irradiation with high doses of UV is almost totally inhibited by aphidicolin, an agent specific for DNA polymerase alpha, and presumably is mediated by that polymerase. Aphidicolin 127-138 DNA polymerase alpha 1, catalytic subunit Homo sapiens 162-182 6423305-2 1984 damage in human fibroblasts is more sensitive to inhibitors of DNA polymerase alpha (cytosine arabinoside, aphidicolin) than to an inhibitor of polymerase beta (dideoxythymidine), which indicates a greater role in repair for polymerase alpha than for polymerase beta. Aphidicolin 107-118 DNA polymerase alpha 1, catalytic subunit Homo sapiens 63-83 6434179-1 1984 A new class of fragile sites termed common fragile sites is induced by aphidicolin, an inhibitor of DNA polymerase alpha. Aphidicolin 71-82 DNA polymerase alpha 1, catalytic subunit Homo sapiens 100-120 6430549-5 1984 The fragmentation of the DNA can be prevented by pretreatment with aphidicolin which inhibits DNA polymerase alpha. Aphidicolin 67-78 DNA polymerase alpha 1, catalytic subunit Homo sapiens 94-114 6431754-5 1984 Considered along with related information reported previously, the present results suggest that both aphidicolin-sensitive and insensitive DNA polymerases, DNA polymerase alpha and a non-alpha DNA polymerase (possibly DNA polymerase beta), are involved in in situ UDS in these ultraviolet-irradiated cells. Aphidicolin 101-112 DNA polymerase alpha 1, catalytic subunit Homo sapiens 156-176 6422050-3 1984 In this study, we used aphidicolin, a specific inhibitor of DNA pol alpha, to assay for the requirement of pol alpha activity in parental RF formation in vivo. Aphidicolin 23-34 DNA polymerase alpha 1, catalytic subunit Homo sapiens 64-73 6418378-5 1984 This was observed in cells synchronized by thymidine excess or by aphidicolin, an inhibitor of DNA polymerase alpha. Aphidicolin 66-77 DNA polymerase alpha 1, catalytic subunit Homo sapiens 95-115 6204821-4 1984 The cells were then treated with bleomycin, which produces DNA strand breakage; proflavine, which intercalates into DNA; mitomycin C, which produces monoadducts and DNA crosslinks; or aphidicolin, which inhibits DNA polymerase alpha. Aphidicolin 184-195 DNA polymerase alpha 1, catalytic subunit Homo sapiens 212-232 6319762-1 1984 Aphidicolin is a potent inhibitor of both host cell DNA polymerase alpha and herpes simplex virus (HSV)-induced DNA polymerase but has no effect on DNA polymerases beta and gamma of host cells. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 52-72 6319762-2 1984 By using an aphidicolin-resistant mutant (Aphr) of HSV, a possible involvement of DNA polymerase alpha in host cell reactivation of UV-damaged HSV was studied. Aphidicolin 12-23 DNA polymerase alpha 1, catalytic subunit Homo sapiens 82-102 6319564-1 1984 Aphidicolin, a tetracyclic diterpenoid which inhibits the DNA polymerase-alpha activities of many eukaryotic cells, inhibited herpes simplex virus growth and DNA synthesis in infected cultures and the activity of the virus DNA polymerase in vitro. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 58-78 6430783-0 1984 DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Aphidicolin 35-46 DNA polymerase alpha 1, catalytic subunit Homo sapiens 0-20 6430783-1 1984 Aphidicolin, a specific inhibitor of DNA polymerase alpha, is known to induce chromosomal aberrations. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 37-57 6430783-7 1984 Aphidicolin represents a novel tool for detection of hot spots on human chromosomes through the mechanism of DNA polymerase alpha inhibition. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 109-129 11478315-1 1984 The mycotoxin aphidicolin specifically inhibits nuclear DNA synthesis in eukaryotic cells by intereacting with the replicative DNA polymerase alpha. Aphidicolin 14-25 DNA polymerase alpha 1, catalytic subunit Homo sapiens 127-147 6408640-1 1983 DNA replication intermediates in human melanoma cells have been investigated by using the drug aphidicolin, which inhibits DNA polymerase alpha. Aphidicolin 95-106 DNA polymerase alpha 1, catalytic subunit Homo sapiens 123-143 6403037-1 1983 Excision repair of ultraviolet damage in human fibroblasts was partially inhibited by drugs that block DNA polymerases alpha or beta (cytosine arabinoside, aphidicolin and dideoxythymidine) causing a reduction in unscheduled synthesis and an accumulation of single-strand breaks. Aphidicolin 156-167 DNA polymerase alpha 1, catalytic subunit Homo sapiens 103-124 6818174-1 1982 Aphidicolin specifically inhibits eukaryotic DNA polymerase alpha, while 2",3"-dideoxythymidine 5"-triphosphate (d2TTP) inhibits DNA polymerase beta and gamma but not alpha. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 45-65 6406250-5 1983 Aphidicolin, a specific inhibitor of eukaryotic DNA polymerase alpha, has no effect on dNTP pool size in 1-methyladenine-treated oocytes, but causes considerable expansion of dNTP pools in fertilized eggs which cleave achromosomally in the presence of the drug. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 48-68 6406086-4 1983 In contrast, if DNA polymerase alpha is inhibited by aphidicolin prior to treatment with ascorbate-Cu2+ one cannot detect the fragmentation of the DNA. Aphidicolin 53-64 DNA polymerase alpha 1, catalytic subunit Homo sapiens 16-36 7151804-4 1982 DNA polymerase alpha is inhibited by N-ethylmaleimide (94% and 100% at 1 mM and 10 mM respectively) and aphidicolin (96% at 60 microM). Aphidicolin 104-115 DNA polymerase alpha 1, catalytic subunit Homo sapiens 0-20 6402775-0 1983 Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha. Aphidicolin 33-44 DNA polymerase alpha 1, catalytic subunit Homo sapiens 55-75 6402775-1 1983 The Chinese hamster V79 cell mutant aphr-4-2, selected for its resistance to aphidicolin, a specific inhibitor of DNA polymerase alpha (DNA nucleotidyltransferase, EC 2.7.7.7), is characterized by slow growth, UV sensitivity, and hypersensitivity to UV-induced mutation. Aphidicolin 77-88 DNA polymerase alpha 1, catalytic subunit Homo sapiens 114-134 6403035-2 1983 The antibiotic, aphidicolin, is a potent inhibitor of DNA polymerase alpha and consequently of de novo DNA synthesis in human cells. Aphidicolin 16-27 DNA polymerase alpha 1, catalytic subunit Homo sapiens 54-74 7162528-4 1982 The single exception was a pair of CS strains from sibling donors in which the rate of uncoupled incision due to the presence of either araC or the specific inhibitor of DNA polymerase alpha, aphidicolin, was slightly faster than in other cells studied. Aphidicolin 192-203 DNA polymerase alpha 1, catalytic subunit Homo sapiens 170-190 6809314-3 1982 The mechanism of inhibition of DNA synthesis in neoplastic cells is again due to the inhibition of DNA polymerase alpha by aphidicolin. Aphidicolin 123-134 DNA polymerase alpha 1, catalytic subunit Homo sapiens 99-119 7102674-2 1982 Inhibition of polymerization and/or ligation of repaired regions with inhibitors of DNA polymerase alpha (cytosine arabinoside and aphidicolin) resulted in the accumulation of single-strand breaks, delayed reconstruction of DNA supercoiling, and maintenance of the staphylococcal nuclease digestibility. Aphidicolin 131-142 DNA polymerase alpha 1, catalytic subunit Homo sapiens 84-104 6809956-3 1982 Aphidicolin, an inhibitor of eucaryotic DNA polymerase alpha, was studied in murine cells infected either permissively or nonpermissively with regard to the Fv-1 genotype. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 40-60 6799808-0 1982 Effect of post-treatment with aphidicolin - a specific inhibitor of DNA polymerase alpha - on sister-chromatid exchanges induced by ethyl methanesulfonate. Aphidicolin 30-41 DNA polymerase alpha 1, catalytic subunit Homo sapiens 68-88 6808155-2 1982 The experiments tested the effects of aphidicolin, which is highly specific for DNA polymerase alpha, and 2",3"-dideoxythymidine-5"-triphosphate (ddTTP), which inhibits cellular DNA polymerases in the order gamma greater than beta greater than alpha. Aphidicolin 38-49 DNA polymerase alpha 1, catalytic subunit Homo sapiens 80-100 7093202-9 1982 Repair synthesis in this system is inhibited by aphidicolin, but not by high levels of dideoxy-TTP, suggesting involvement of DNA polymerase alpha in excision repair. Aphidicolin 48-59 DNA polymerase alpha 1, catalytic subunit Homo sapiens 126-146 6820927-3 1982 DNA synthesis in short-time organ cultures of isolated epidermis was strongly inhibited by aphidicolin, suggesting that DNA polymerase alpha is involved in DNA replication in human epidermis. Aphidicolin 91-102 DNA polymerase alpha 1, catalytic subunit Homo sapiens 120-140 6784928-0 1981 New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha. Aphidicolin 72-83 DNA polymerase alpha 1, catalytic subunit Homo sapiens 109-129 6795595-0 1981 Aphidicolin inhibits DNA synthesis by DNA polymerase alpha and isolated nuclei by a similar mechanism. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 38-58 6795595-1 1981 Aphidicolin is a selective inhibitor of DNA polymerase alpha. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 40-60 6785339-1 1981 We have developed a method, based on the in vitro inhibition of purified human DNA polymerase alpha, the major enzyme of DNA replication, which allows the rapid and accurate determination of pmol amounts of aphidicolin, a promising anticancer drug. Aphidicolin 207-218 DNA polymerase alpha 1, catalytic subunit Homo sapiens 79-99 6793260-1 1981 Aphidicolin is a specific inhibitor of DNA polymerase alpha. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 39-59 6793260-8 1981 The data therefore indicate that aphidicolin prevents the rejoining of single strand breaks formed during the excision repair process and imply that DNA polymerase alpha is involved in the repair of DNA in human cells. Aphidicolin 33-44 DNA polymerase alpha 1, catalytic subunit Homo sapiens 149-169 6799347-1 1981 The effects of aphidicolin - a powerful inhibitor of DNA polymerase alpha and of DNA replication - on normal development and on differentiation without cleavage of Chaetopterus eggs have been studied with cytological, cytochemical, and biochemical methods. Aphidicolin 15-26 DNA polymerase alpha 1, catalytic subunit Homo sapiens 53-73 6260987-10 1981 The results with the specific inhibitors of mammalian DNA polymerases, aphidicolin, N-ethylmaleimide, and 2",3"-dideoxythymidine 5"-triphosphate indicated that DNA polymerase alpha was required for synthesis of parvoviral DNA in the nuclear lysates. Aphidicolin 71-82 DNA polymerase alpha 1, catalytic subunit Homo sapiens 160-180 6777385-1 1980 Aphidicolin, a known inhibitor of DNA polymerase alpha, is a potent inhibitor of nuclear DNA synthesis in HeLa cells but has no effect on the replication of mitochondrial DNA. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 34-54 6790638-0 1980 [Aphidicolin: a specific inhibitor of eukaryotic DNA polymerase alpha (author"s transl)]. Aphidicolin 1-12 DNA polymerase alpha 1, catalytic subunit Homo sapiens 49-69 526293-0 1979 Aphidicolin resistant mutant of which DNA polymerase alpha is induced by this drug. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 38-58 6775308-0 1980 Synchronization of HeLa cell cultures by inhibition of DNA polymerase alpha with aphidicolin. Aphidicolin 81-92 DNA polymerase alpha 1, catalytic subunit Homo sapiens 55-75 6783033-1 1980 We have studied the DNA repair synthesis in HeLa cell isolated nuclei in presence of aphidicolin, which selectively inhibits DNA polymerase alpha but not DNA polymerases beta and gamma. Aphidicolin 85-96 DNA polymerase alpha 1, catalytic subunit Homo sapiens 125-145 117431-8 1979 By contrast, aphidicolin, a specific inhibitor of DNA polymerase alpha, inhibits DNA repair and replicative synthesis in both intact and permeabilized cells. Aphidicolin 13-24 DNA polymerase alpha 1, catalytic subunit Homo sapiens 50-70 450707-2 1979 Aphidicolin inhibited DNA synthesis and DNA polymerase alpha very efficiently whereas DNA polymerases beta and gamma were insensitive to the drug. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 40-60 475808-0 1979 Aphidicolin inhibits eukaryotic DNA replication and repair --- implications for involvement of DNA polymerase alpha in both processes. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 95-115 31403790-1 2019 Aphidicolin, a potent DNA polymerase alpha inhibitor, has been explored in clinical trials for the treatment of cancer. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 22-42 692726-0 1978 Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 79-99 31026293-4 2019 Specifically, inhibition of Pol alpha by small molecule inhibitors aphidicolin or CD437 as well as silencing of Pol alpha expression by siRNA led to suppression of cccDNA amplification in human hepatoma cells. Aphidicolin 67-78 DNA polymerase alpha 1, catalytic subunit Homo sapiens 28-37 25429975-4 2014 Here we report the crystal structure of the catalytic core of human DNA polymerase alpha (Pol alpha) in the ternary complex with an RNA-primed DNA template and aphidicolin. Aphidicolin 160-171 DNA polymerase alpha 1, catalytic subunit Homo sapiens 68-88 25429975-4 2014 Here we report the crystal structure of the catalytic core of human DNA polymerase alpha (Pol alpha) in the ternary complex with an RNA-primed DNA template and aphidicolin. Aphidicolin 160-171 DNA polymerase alpha 1, catalytic subunit Homo sapiens 90-99 25429975-6 2014 The structure provides a plausible mechanism for the selectivity of aphidicolin incorporation opposite template guanine and explains why previous modifications of aphidicolin failed to improve its affinity for Pol alpha. Aphidicolin 68-79 DNA polymerase alpha 1, catalytic subunit Homo sapiens 210-219 25429975-6 2014 The structure provides a plausible mechanism for the selectivity of aphidicolin incorporation opposite template guanine and explains why previous modifications of aphidicolin failed to improve its affinity for Pol alpha. Aphidicolin 163-174 DNA polymerase alpha 1, catalytic subunit Homo sapiens 210-219 14603443-4 2004 Exposure to aphidicolin, an inhibitor of DNA polymerase alpha, results in a modest increase in cells with replication of FRA16D sequences in early S phase. Aphidicolin 12-23 DNA polymerase alpha 1, catalytic subunit Homo sapiens 41-61 19269999-6 2009 In isolated nuclei, PGG inhibited DNA replicative synthesis with superior efficacy than a known DNA polymerase alpha inhibitor, aphidocolin. Aphidicolin 128-139 DNA polymerase alpha 1, catalytic subunit Homo sapiens 96-116 18616816-6 2008 This effect was enhanced by the induction of DNA replication stress using the DNA polymerase alpha inhibitor aphidicolin. Aphidicolin 109-120 DNA polymerase alpha 1, catalytic subunit Homo sapiens 78-98 18341260-5 2008 Furthermore, the study could explain, at least partially, the inhibitory effect of aphidicolin on pol alpha. Aphidicolin 83-94 DNA polymerase alpha 1, catalytic subunit Homo sapiens 98-107 15309689-6 2004 We found that, compared with controls, there is greater chromosomal instability, particularly at fragile sites, in SCKL1-affected patient cells after treatment with aphidicolin, an inhibitor of DNA polymerase alpha and other polymerases. Aphidicolin 165-176 DNA polymerase alpha 1, catalytic subunit Homo sapiens 194-214 12688717-0 2003 Diastereoselective formal total synthesis of the DNA polymerase alpha inhibitor, aphidicolin, using palladium-catalyzed cycloalkenylation and intramolecular Diels-Alder reactions. Aphidicolin 81-92 DNA polymerase alpha 1, catalytic subunit Homo sapiens 49-69 10342290-6 1999 Aphidicolin is an inhibitor of cellular DNA polymerase alpha, and it halts progression of the cell cycle at the G1/S border or early S phase. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 40-60 12459445-3 2002 The efficiency of bypass in the human large-cell lung carcinoma cell line H1299 was 80%, and it was similar when assayed in the presence of aphidicolin, an inhibitor of DNA polymerases alpha, delta and epsilon. Aphidicolin 140-151 DNA polymerase alpha 1, catalytic subunit Homo sapiens 169-209 11891323-8 2002 Addition of aphidicolin, an inhibitor of DNA polymerases alpha, delta, and epsilon, caused a 4.4-fold inhibition of bypass. Aphidicolin 12-23 DNA polymerase alpha 1, catalytic subunit Homo sapiens 41-82 12149019-1 2002 To examine the mechanism of the cyclization reaction catalyzed by aphidicolan-16beta-ol synthase (ACS), which is a key enzyme in the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha, skeletal rearrangement of 2a and biomimetic cyclization of 4b were employed. Aphidicolin 159-170 DNA polymerase alpha 1, catalytic subunit Homo sapiens 196-216 11827715-1 2002 Cytotoxic and mutagenic effects of aphidicolin (APC), an inhibitor of DNA polymerases alpha and delta, were studied in human diploid VH-10 fibroblasts. Aphidicolin 35-46 DNA polymerase alpha 1, catalytic subunit Homo sapiens 70-91 9530343-2 1998 We wished to determine whether aphidicolin (APC), an inhibitor of the DNA repair enzyme DNA polymerase alpha, could be used as a reliable biomarker in identification of DNA repair capacity in unaffected individuals at high risk from breast cancer families. Aphidicolin 31-42 DNA polymerase alpha 1, catalytic subunit Homo sapiens 88-108 9637237-9 1998 Aphidicolin, an inhibitor of DNA polymerases alpha/delta/epsilon. Aphidicolin 0-11 DNA polymerase alpha 1, catalytic subunit Homo sapiens 29-64 9499431-7 1998 Exposure to aphidicolin, an inhibitor of both DNA polymerase alpha and delta, results in a reproducible delay in the timing of replication, and some cells enter G2without having completed replication of FRA3B sequences. Aphidicolin 12-23 DNA polymerase alpha 1, catalytic subunit Homo sapiens 46-66 9802062-5 1998 The cell lines were exposed to CPT in the presence or absence of aphidicolin, an inhibitor of DNA polymerases alpha, delta or epsilon. Aphidicolin 65-76 DNA polymerase alpha 1, catalytic subunit Homo sapiens 94-133 9057979-2 1997 The strand breaks were detected by an alkaline elution method with the use of inhibitors of DNA polymerase, aphidicolin (aph) and 2",3"-dideoxythymidine (ddT); the former inhibits DNA polymerases alpha, delta and epsilon, and the latter inhibits DNA polymerase beta. Aphidicolin 108-119 DNA polymerase alpha 1, catalytic subunit Homo sapiens 180-265 9455920-8 1997 Treatment of K562 cells with erythropoietin (EPO) or with aphidicolin (APH), an inhibitor for DNA polymerase alpha, induced an erythroid phenotype and led to the externalization of cytosolic GAL1 which was then bound to ligands on cell surface in a galactoside-inhibitable fashion. Aphidicolin 58-69 DNA polymerase alpha 1, catalytic subunit Homo sapiens 94-114 8840989-6 1996 That the DNA replication process is prerequisite for DNA double strand breaks was indicated by the following: (a) DNA damage occurred only when cells treated with ZD1694 progressed through S phase; and (b) the inhibition of DNA polymerase alpha by aphidicolin-blocked DNA damage. Aphidicolin 248-259 DNA polymerase alpha 1, catalytic subunit Homo sapiens 224-244 8871556-9 1996 An inhibitor of Polbeta, ddCTP, decreased base excision repair in crude extracts by approximately 50%, whereas the Polalpha/delta/epsilon inhibitor, aphidicolin, reduced the reaction by approximately 20%. Aphidicolin 149-160 DNA polymerase alpha 1, catalytic subunit Homo sapiens 115-123 8800198-5 1996 To assess the role of S phase progression in radiosensitization, we exposed FdUrd-treated cells to aphidicolin, an inhibitor of DNA polymerase alpha, prior to irradiation. Aphidicolin 99-110 DNA polymerase alpha 1, catalytic subunit Homo sapiens 128-148 8646799-7 1996 Furthermore, a component of the nucleotide excision repair (NER) pathway, DNA polymerase alpha, was investigated using the competitive inhibitor aphidicolin. Aphidicolin 145-156 DNA polymerase alpha 1, catalytic subunit Homo sapiens 74-94 8860956-4 1996 The DNA damage induced by the exposure to PQ alone was different from that by DMAA; PQ-induced damage was fully repaired after 24 h, while DMAA-induced damage was repaired only partially, and aphidicolin, an inhibitor of repair-serving DNA polymerases alpha, delta and/or epsilon, inhibited only the latter repair but not the former. Aphidicolin 192-203 DNA polymerase alpha 1, catalytic subunit Homo sapiens 236-279 8813556-9 1996 In addition, the acquired resistance and enhanced DNA repair in HOB1/VCR cells were partially reversed by nontoxic aphidicolin, a DNA polymerase-alpha and DNA repair inhibitor. Aphidicolin 115-126 DNA polymerase alpha 1, catalytic subunit Homo sapiens 130-150 7529174-9 1994 Treatment of MDM with aphidicolin, a specific inhibitor of DNA polymerase alpha and delta which arrests cells in G1/S phase of the cell cycle, also inhibited DNA synthesis but did not prevent establishment of productive infection which is completely analogous to observations in T cells. Aphidicolin 22-33 DNA polymerase alpha 1, catalytic subunit Homo sapiens 59-79 8825452-5 1996 The activity was markedly inhibited by aphidicolin which is an inhibitor of mammalian DNA polymerases alpha, delta, and epsilon and also by N-ethylmaleimide which is an inhibitor of DNA polymerases, alpha, gamma, delta and epsilon. Aphidicolin 39-50 DNA polymerase alpha 1, catalytic subunit Homo sapiens 86-107 8825452-5 1996 The activity was markedly inhibited by aphidicolin which is an inhibitor of mammalian DNA polymerases alpha, delta, and epsilon and also by N-ethylmaleimide which is an inhibitor of DNA polymerases, alpha, gamma, delta and epsilon. Aphidicolin 39-50 DNA polymerase alpha 1, catalytic subunit Homo sapiens 182-230 7918625-1 1994 DNA polymerases involved in ultraviolet (UV)-induced DNA repair were studied in human fibroblasts using the inhibitors of DNA polymerases, aphidicolin which inhibits DNA polymerases alpha, delta and epsilon, and butylphenyldeoxyguanosine (BuPGdR) which inhibits DNA polymerase alpha strongly and weakly inhibits delta and epsilon. Aphidicolin 139-150 DNA polymerase alpha 1, catalytic subunit Homo sapiens 166-246 7805758-11 1994 Furthermore, the acquired resistance in HeLa cells was partially reversed by nontoxic aphidicolin, a DNA polymerase-alpha and DNA repair inhibitor. Aphidicolin 86-97 DNA polymerase alpha 1, catalytic subunit Homo sapiens 101-121 8137287-4 1994 This effect was abolished by cotreatment with the DNA polymerase alpha inhibitor aphidicolin. Aphidicolin 81-92 DNA polymerase alpha 1, catalytic subunit Homo sapiens 50-70 8267640-1 1993 We investigated the effect of aphidicolin, an inhibitor of DNA polymerase alpha and delta, on the induction of apoptosis by arabinosyl nucleosides in a human promyelocytic leukemia cell line, HL-60. Aphidicolin 30-41 DNA polymerase alpha 1, catalytic subunit Homo sapiens 59-79