| 1 |
35124898 | The Gαs-protein-mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors. | 2022 Apr |
1 |
| 2 |
35256606 | A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration. | 2022 Mar 8 |
1 |
| 3 |
33158942 | Prostanoid Receptors of the EP4-Subtype Mediate Gene Expression Changes in Human Airway Epithelial Cells with Potential Anti-Inflammatory Activity. | 2021 Feb |
1 |
| 4 |
33543288 | Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages. | 2021 Jan 22 |
1 |
| 5 |
34502044 | Prostaglandin E2 Receptor 4 (EP4) Affects Trophoblast Functions via Activating the cAMP-PKA-pCREB Signaling Pathway at the Maternal-Fetal Interface in Unexplained Recurrent Miscarriage. | 2021 Aug 24 |
1 |
| 6 |
34927727 | Prostaglandin signaling in ciliogenesis and development. | 2021 Dec 20 |
1 |
| 7 |
31820176 | Prostaglandins and Bone. | 2020 |
1 |
| 8 |
31884570 | Agonist-specific desensitization of PGE2-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts. | 2020 May |
2 |
| 9 |
32240179 | Interleukin-10 contributes to PGE2 signalling through upregulation of EP4 via SHIP1 and STAT3. | 2020 |
3 |
| 10 |
32363546 | COX-2-PGE2-EPs in gynecological cancers. | 2020 Jun |
1 |
| 11 |
32438662 | Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E2 Activation in Human Podocytes. | 2020 May 19 |
1 |
| 12 |
32547404 | Eicosanoids in Cancer: Prostaglandin E2 Receptor 4 in Cancer Therapeutics and Immunotherapy. | 2020 |
1 |
| 13 |
32727851 | 15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling. | 2020 Sep 18 |
1 |
| 14 |
33643295 | Characterization of the Signaling Modalities of Prostaglandin E2 Receptors EP2 and EP4 Reveals Crosstalk and a Role for Microtubules. | 2020 |
11 |
| 15 |
30517642 | Insights Into Local Orbital Immunity: Evidence for the Involvement of the Th17 Cell Pathway in Thyroid-Associated Ophthalmopathy. | 2019 May 1 |
1 |
| 16 |
30536718 | EP2 and EP4 receptor antagonists: Impact on cytokine production and β2 -adrenergic receptor desensitization in human airway smooth muscle. | 2019 Jul |
1 |
| 17 |
30835912 | PGE2 -induced migration of human brain endothelial cell is mediated though protein kinase A in cooperation of EP receptors. | 2019 Apr |
1 |
| 18 |
30980797 | Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells. | 2019 Jun 15 |
1 |
| 19 |
31455205 | Improved homology modeling of the human & rat EP4 prostanoid receptors. | 2019 Aug 27 |
1 |
| 20 |
31871536 | Prostaglandin E2 signal inhibits T regulatory cell differentiation during allergic rhinitis inflammation through EP4 receptor. | 2019 Dec |
2 |
| 21 |
29328471 | Prostaglandin E2 receptor EP4 is involved in the cell growth and invasion of prostate cancer via the cAMP‑PKA/PI3K‑Akt signaling pathway. | 2018 Mar |
4 |
| 22 |
28607093 | Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength. | 2017 Jun 27 |
1 |
| 23 |
29290997 | Targeting G-protein coupled receptor-related signaling pathway in a murine xenograft model of appendiceal pseudomyxoma peritonei. | 2017 Dec 5 |
1 |
| 24 |
26826430 | Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition. | 2016 Mar 15 |
1 |
| 25 |
25220136 | Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling. | 2015 Jan |
1 |
| 26 |
25433165 | Interplay between the prostaglandin transporter OATP2A1 and prostaglandin E2-mediated cellular effects. | 2015 Mar |
1 |
| 27 |
26204403 | The effect of hypoxia on PGE2-stimulated cAMP generation in HMEC-1. | 2015 Jun |
2 |
| 28 |
26228894 | Prostaglandin E-mediated molecular mechanisms driving remodeling of the ductus arteriosus. | 2015 Oct |
3 |
| 29 |
26403276 | The stellate vascular smooth muscle cell phenotype is induced by IL-1β via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation. | 2015 Dec |
1 |
| 30 |
26415983 | Regulation of PGE2 signaling pathways and TNF-alpha signaling pathways on the function of bone marrow-derived dendritic cells and the effects of CP-25. | 2015 Dec 15 |
1 |
| 31 |
26508788 | Phosphorylation of STAT3 mediates the induction of cyclooxygenase-2 by cortisol in the human amnion at parturition. | 2015 Oct 27 |
1 |
| 32 |
26518053 | Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells. | 2015 Dec 5 |
1 |
| 33 |
24760659 | PGE2 modulates the transcriptional activity of ERRa in prostate stromal cells. | 2014 Dec |
1 |
| 34 |
25109834 | Prostaglandin E2 promotes the cell growth and invasive ability of hepatocellular carcinoma cells by upregulating c-Myc expression via EP4 receptor and the PKA signaling pathway. | 2014 Oct |
2 |
| 35 |
25173977 | Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. | 2014 Sep |
2 |
| 36 |
25505603 | Regulation of prostaglandin EP1 and EP4 receptor signaling by carrier-mediated ligand reuptake. | 2014 Oct |
1 |
| 37 |
22947771 | α-Tocopherol (vitamin E) stimulates cyclic AMP production in human peripheral mononuclear cells and alters immune function. | 2013 Mar |
1 |
| 38 |
23265688 | Prostaglandin E2/EP4 signalling facilitates EP4 receptor externalization in primary sensory neurons in vitro and in vivo. | 2013 Feb |
2 |
| 39 |
23575689 | Prostaglandin E₂ promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase. | 2013 |
2 |
| 40 |
23656623 | Phosphodiesterase-4 inhibition augments human lung fibroblast vascular endothelial growth factor production induced by prostaglandin E2. | 2013 Oct |
1 |
| 41 |
23742099 | H2O2 stimulates cystic fibrosis transmembrane conductance regulator through an autocrine prostaglandin pathway, using multidrug-resistant protein-4. | 2013 Oct |
1 |
| 42 |
23904482 | Neuronal prostaglandin E2 receptor subtype EP3 mediates antinociception during inflammation. | 2013 Aug 13 |
1 |
| 43 |
22108211 | C6orf176: a novel possible regulator of cAMP-mediated gene expression. | 2012 Feb 1 |
3 |
| 44 |
22844123 | Prostaglandin E₂ induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway. | 2012 Sep 1 |
1 |
| 45 |
22933297 | Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia. | 2012 Nov 15 |
1 |
| 46 |
22977257 | Prostaglandin E2-induced IL-23p19 subunit is regulated by cAMP-responsive element-binding protein and C/AATT enhancer-binding protein β in bone marrow-derived dendritic cells. | 2012 Oct 26 |
1 |
| 47 |
20883477 | Lubiprostone targets prostanoid EP₄ receptors in ovine airways. | 2011 Jan |
2 |
| 48 |
21185865 | Regulatory mechanism of duodenal bicarbonate secretion: Roles of endogenous prostaglandins and nitric oxide. | 2011 Apr |
1 |
| 49 |
20145136 | Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model. | 2010 Feb 15 |
3 |
| 50 |
20551589 | Regulation of vascular tone and remodeling of the ductus arteriosus. | 2010 |
2 |