Cyclic AMP

prostaglandin E receptor 4 ; Homo sapiens







102 Article(s)
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51 20558773 Prostaglandin E2 inhibits advanced glycation end product-induced adhesion molecule expression on monocytes, cytokine production, and lymphocyte proliferation during human mixed lymphocyte reaction. 2010 Sep 1 1
52 20664890 Selective activation of the prostaglandin E2 receptor subtype EP2 or EP4 leads to inhibition of platelet aggregation. 2010 Oct 1
53 18843255 Hypertonicity stimulates PGE2 signaling in the renal medulla by promoting EP3 and EP4 receptor expression. 2009 Feb 2
54 18849297 Human papillomavirus E5 protein induces expression of the EP4 subtype of prostaglandin E2 receptor in cyclic AMP response element-dependent pathways in cervical cancer cells. 2009 Jan 2
55 19445930 Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models. 2009 Nov 1
56 19454659 Pollen-derived E1-phytoprostanes signal via PPAR-gamma and NF-kappaB-dependent mechanisms. 2009 Jun 1 1
57 19464664 Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA. 2009 Jun 1
58 19545899 CCR7-specific migration to CCL19 and CCL21 is induced by PGE(2) stimulation in human monocytes: Involvement of EP(2)/EP(4) receptors activation. 2009 Aug 1
59 18467512 Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms. 2008 Aug 1 1
60 17130837 Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells. 2007 May 10 6
61 17244328 Prostaglandin E2 inhibition of keloid fibroblast migration, contraction, and transforming growth factor (TGF)-beta1-induced collagen synthesis. 2007 Jan-Feb 1
62 17427962 Prostaglandin E2 induces vascular endothelial growth factor secretion in prostate cancer cells through EP2 receptor-mediated cAMP pathway. 2007 Nov 1
63 16257278 Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts. 2006 Mar 1
64 16827895 E prostanoid 2 (EP2)/EP4-mediated suppression of antigen-specific human T-cell responses by prostaglandin E2. 2006 Jul 1
65 15626689 PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK and EGFR transactivation. 2005 May 3
66 15694412 Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation. 2005 Mar 18 1
67 15855407 Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin E2. 2005 Jul 3
68 15948687 Cyclooxygenase-2-dependent prostaglandin (PG) E2 downregulates matrix metalloproteinase-3 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells stimulated with interleukin-1alpha. 2005 Jun 2
69 15970595 Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites. 2005 Aug 26 1
70 15985651 Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells. 2005 Nov 2
71 16262658 Stimulation of PGE receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following beta-amyloid exposure. 2005 Nov 5
72 29539150 Cyclooxygenase-2-Dependent Prostaglandin (PG) E2 Downregulates Matrix Metalloproteinase-3 Production via EP2 /EP4 Subtypes of PGE2 Receptors in Human Periodontal Ligament Cells Stimulated With Interleukin-1α. 2005 Jun 2
73 14715958 Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. 2004 Jan 7 1
74 12837940 Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. 2003 Jul 22 1
75 12970327 Prostaglandin E2 induces proliferation of glandular epithelial cells of the human endometrium via extracellular regulated kinase 1/2-mediated pathway. 2003 Sep 1
76 14499627 Role of prostaglandin E2 receptors in migration of murine and human breast cancer cells. 2003 Oct 1 2
77 14517215 Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors. 2003 Dec 12 1
78 14558087 Prostaglandin E2 is an enhancer of interleukin-1beta-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts. 2003 Oct 1
79 11997037 Prostaglandin E2 reinforces the activation of Ras signal pathway in lung adenocarcinoma cells via EP3. 2002 May 8 1
80 12149218 Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. 2002 Aug 15 1
81 12209094 Characterization of PGE2 receptor subtypes in human eosinophils. 2002 Sep 2
82 12393872 Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. 2002 Dec 27 1
83 12445196 Cyclooxygenase-2 inhibitor enhances whereas prostaglandin E2 inhibits the production of interferon-induced protein of 10 kDa in epidermoid carcinoma A431. 2002 Nov 1
84 12468638 Seminal plasma activates cyclooxygenase-2 and prostaglandin E2 receptor expression and signalling in cervical adenocarcinoma cells. 2002 Dec 2
85 11344234 Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. 2001 May 1
86 11418617 Arrestin specificity for G protein-coupled receptors in human airway smooth muscle. 2001 Aug 31 1
87 11447018 PGE2 triggers recovery of transmucosal resistance via EP receptor cross talk in porcine ischemia-injured ileum. 2001 Aug 1
88 11549693 Expression, localization, and signaling of PGE(2) and EP2/EP4 receptors in human nonpregnant endometrium across the menstrual cycle. 2001 Sep 1
89 11592775 Expression of COX-2 and PGE synthase and synthesis of PGE(2)in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. 2001 Sep 28 1
90 11597569 Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail. 2001 Oct 15 4
91 11154420 Prostaglandins E2 and I2 downregulate tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human oral gingival epithelial cells. 2000 Oct 1
92 9888433 Expression of prostaglandin receptors EP4 and FP in human lens epithelial cells. 1999 Jan 7
93 10697805 Prostaglandin E2 receptors of the EP2 and EP4 subtypes downregulate tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human gingival fibroblasts. 1999 Nov 1
94 9732406 EP4/EP2 receptor-specific prostaglandin E2 regulation of interleukin-6 generation by human HSB.2 early T cells. 1998 Sep 1
95 9736261 Regulation of renal function by prostaglandin E receptors. 1998 Sep 1
96 9759900 Prostaglandin E2 stimulates IL-8 gene expression in human colonic epithelial cells by a posttranscriptional mechanism. 1998 Oct 1 1
97 9788776 A conserved threonine in the second extracellular loop of the human EP2 and EP4 receptors is required for ligand binding. 1998 Sep 11 1
98 9214685 Detection of EP2, EP4, and FP receptors in human ciliary epithelial and ciliary muscle cells. 1997 May 9 2
99 8604222 A molecular analysis of PGE receptor (EP) expression on normal and transformed B lymphocytes: coexpression of EP1, EP2, EP3beta and EP4. 1996 Jan 1
100 8862514 Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester. 1996 Jun 1