Title : Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength.

Pub. Date : 2017 Jun 27

PMID : 28607093






1 Functional Relationships(s)
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1 Mechanistically, the PGE2 EP4 interaction causes MuSC expansion by triggering a cAMP/phosphoCREB pathway that activates the proliferation-inducing transcription factor, Nurr1 Our findings reveal that loss of PGE2 signaling to MuSCs during recovery from injury impedes muscle repair and strength. Cyclic AMP prostaglandin E receptor 4 Homo sapiens