Title : Polymorphisms of the UDP-glucuronosyl transferase 1A genes are associated with adverse events in cancer patients receiving irinotecan-based chemotherapy.

Pub. Date : 2013 Feb

PMID : 23303296






5 Functional Relationships(s)
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1 Since SN-38 is metabolized to non-toxic SN-38-glucuronide by hepatic uridine diphosphate glucuronosyl transferase (UGT) 1A enzymes, UGT1A enzyme activities may influence adverse events of CPT-11. Irinotecan UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens
2 Since SN-38 is metabolized to non-toxic SN-38-glucuronide by hepatic uridine diphosphate glucuronosyl transferase (UGT) 1A enzymes, UGT1A enzyme activities may influence adverse events of CPT-11. Irinotecan UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens
3 Since SN-38 is metabolized to non-toxic SN-38-glucuronide by hepatic uridine diphosphate glucuronosyl transferase (UGT) 1A enzymes, UGT1A enzyme activities may influence adverse events of CPT-11. Irinotecan UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens
4 Since SN-38 is metabolized to non-toxic SN-38-glucuronide by hepatic uridine diphosphate glucuronosyl transferase (UGT) 1A enzymes, UGT1A enzyme activities may influence adverse events of CPT-11. Irinotecan UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens
5 Here, to identify the genetic factors that affect the adverse events of CPT-11, we determined the polymorphism in three UGT 1A isozyme genes in 45 inpatients with lung, colon, or stomach cancer. Irinotecan UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens