Temozolomide

isocitrate dehydrogenase (NADP(+)) 1 ; Homo sapiens







48 Article(s)
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1 34969742 Association of MGMT Gene Promoter Methylation With Clinicopathological Parameters in Patients With Wild-type IDH Glioblastoma. 2022 Jan 2
2 35173295 Synergy between TMZ and individualized multimodal immunotherapy to improve overall survival of IDH1 wild-type MGMT promoter-unmethylated GBM patients. 2022 Feb 16 1
3 35351796 Sex-Dependent Analysis of Temozolomide-Induced Myelosuppression and Effects on Survival in a Large Real-life Cohort of Patients With Glioma. 2022 May 17 1
4 35351965 Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain. 2022 Mar 28 1
5 35452002 PET With 11C-Methyl-l-Methionine as a Predictor of Consequential Outcomes at the Time of Discontinuing Temozolomide-Adjuvant Chemotherapy in Patients With Residual IDH-Mutant Lower-Grade Glioma. 2022 Jul 1 2
6 33296093 Post-treatment hypermutation in a recurrent diffuse glioma with H3.3 p.G34 Mutation. 2021 Apr 5
7 33400009 Low MGMT digital expression is associated with a better outcome of IDH1 wildtype glioblastomas treated with temozolomide. 2021 Jan 1
8 33432322 IDH-Mutant Astrocytoma With Chromosome 19q13 Deletion Manifesting as an Oligodendroglioma-Like Morphology. 2021 Feb 22 2
9 33475680 The Role of Temozolomide in Patients With Newly Diagnosed Wild-Type IDH, Unmethylated MGMTp Glioblastoma During the COVID-19 Pandemic. 2021 May 1 1
10 33524191 Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort. 2021 May 4
11 33628600 Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma. 2021 Feb 15 3
12 33823014 Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas. 2021 Nov 2 1
13 33914057 Prognostic significance of genome-wide DNA methylation profiles within the randomized, phase 3, EORTC CATNON trial on non-1p/19q deleted anaplastic glioma. 2021 Sep 1 1
14 34067729 From Laboratory Studies to Clinical Trials: Temozolomide Use in IDH-Mutant Gliomas. 2021 May 17 4
15 34335021 Sensitivity Assessment of Wilms Tumor Gene (WT1) Expression in Glioblastoma using qPCR and Immunohistochemistry and its Association with IDH1 Mutation and Recurrence Interval. 2021 1
16 34830935 A Simple Preoperative Blood Count to Stratify Prognosis in Isocitrate Dehydrogenase-Wildtype Glioblastoma Patients Treated with Radiotherapy plus Concomitant and Adjuvant Temozolomide. 2021 Nov 18 1
17 34934580 GammaTile Brachytherapy Combined With External Beam Radiation Therapy for the Treatment of a Partially Resected Secondary Glioblastoma (WHO Grade 4 IDH-Mutant Astrocytoma): Matching External Beam Dose Gradient to Brachytherapy Dose Fall-Off. 2021 Nov 2
18 32166314 MGMT promoter methylation level in newly diagnosed low-grade glioma is a predictor of hypermutation at recurrence. 2020 Nov 26 2
19 32942564 XGBoost Improves Classification of MGMT Promoter Methylation Status in IDH1 Wildtype Glioblastoma. 2020 Sep 15 1
20 32958546 Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment. 2020 Nov 15 4
21 33255358 Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells. 2020 Nov 24 1
22 30446361 Tumour volume reduction following PET guided intensity modulated radiation therapy and temozolomide in IDH mutated anaplastic glioma. 2019 Jan 1
23 30536544 Hypermutagenesis in untreated adult gliomas due to inherited mismatch mutations. 2019 Jun 15 1
24 30771200 A multicenter phase II study of temozolomide plus disulfiram and copper for recurrent temozolomide-resistant glioblastoma. 2019 May 2
25 30863099 Treatment of adult brainstem glioma with combined antiangiogenic therapy: a case report and literature review. 2019 1
26 31443404 Next Generation Sequencing-Based Transcriptome Predicts Bevacizumab Efficacy in Combination with Temozolomide in Glioblastoma. 2019 Aug 22 1
27 28887717 Prognostic importance of temozolomide-induced neutropenia in glioblastoma, IDH-wildtype patients. 2018 Apr 2
28 29393185 Perspectives of Personalized Chemotherapy of Gliomas Based on Molecular Tumor Profiling. 2018 1
29 29625108 Oncogenic MicroRNA-20a is downregulated by the HIF-1α/c-MYC pathway in IDH1 R132H-mutant glioma. 2018 May 23 1
30 29679127 [Basic principles of diagnosis and treatment of gliomas]. 2018 Jun 1
31 29848907 MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas. 2018 Jul 15 1
32 28202508 Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair. 2017 Apr 1 1
33 28427200 IDH1 R132H mutation regulates glioma chemosensitivity through Nrf2 pathway. 2017 Apr 25 4
34 28571041 CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells. 2017 Jun 27 1
35 28625978 The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion-Mediated Cytotoxicity. 2017 Aug 1 3
36 26911558 IDH mutations may not preclude distant, trans-tentorial spread in gliomas: a case report and review of the literature. 2016 Feb 24 1
37 26936071 Systematic analysis of overall survival and interactions between tumor mutations and drug treatment. 2016 Mar 2 2
38 27764705 IDH mutation and MGMT promoter methylation are associated with the pseudoprogression and improved prognosis of glioblastoma multiforme patients who have undergone concurrent and adjuvant temozolomide-based chemoradiotherapy. 2016 Dec 4
39 25283382 Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation. 2015 Feb 4
40 26373279 Spatiotemporal Evolution of the Primary Glioblastoma Genome. 2015 Sep 14 2
41 24162810 Chemoradiation for anaplastic oligodendrogliomas: clinical outcomes and prognostic value of molecular markers. 2014 Jan 1
42 24305712 Increased sensitivity to radiochemotherapy in IDH1 mutant glioblastoma as demonstrated by serial quantitative MR volumetry. 2014 Mar 2
43 24748470 IDH1 mutation and MGMT methylation status predict survival in patients with anaplastic astrocytoma treated with temozolomide-based chemoradiotherapy. 2014 Jun 2
44 25035396 Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance. 2014 Sep 1 6
45 22752663 IDH1 mutation as a potential novel biomarker for distinguishing pseudoprogression from true progression in patients with glioblastoma treated with temozolomide and radiotherapy. 2013 Apr 1
46 22291938 Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China. 2012 1
47 20975057 IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas. 2010 Oct 26 1
48 19933982 IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide. 2009 Nov 24 1