Pub. Date : 2014 Sep 1
PMID : 25035396
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance. | Temozolomide | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | Isocitrate dehydrogenase 1 (IDH1) mutations occur in most lower grade glioma and not only drive gliomagenesis but are also associated with longer patient survival and improved response to temozolomide. | Temozolomide | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | Isocitrate dehydrogenase 1 (IDH1) mutations occur in most lower grade glioma and not only drive gliomagenesis but are also associated with longer patient survival and improved response to temozolomide. | Temozolomide | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 4 | These results show that mutant IDH1 drives a unique set of transformative events that indirectly enhance HR and facilitate repair of temozolomide-induced DNA damage and temozolomide resistance. | Temozolomide | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 5 | These results show that mutant IDH1 drives a unique set of transformative events that indirectly enhance HR and facilitate repair of temozolomide-induced DNA damage and temozolomide resistance. | Temozolomide | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 6 | The results also suggest that inhibitors of HR may be a viable means to enhance temozolomide response in IDH1-mutant glioma. | Temozolomide | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |