dual specificity phosphatase 2 ; Homo sapiens






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1 1326212 Tumor debulking followed by immediate combination chemotherapy in advanced ovarian carcinoma. Phase II. Acta Obstet Gynecol Scand 1992 Jul 3
2 1326524 Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9. J Biol Chem 1992 Sep 15 3
3 1517241 A molecular model of RGD ligands. Antibody D gene segments that direct specificity for the integrin alpha IIb beta 3. J Biol Chem 1992 Sep 5 4
4 2673929 Functional expression of human glucose-6-phosphate dehydrogenase in Escherichia coli. Gene 1989 May 30 5
5 3100533 Induction of the fibrinogen receptor on human platelets by intracellular mediators. J Biol Chem 1987 Jan 25 15
6 3576380 Radical surgery in patients referred with a diagnosis of unresectable ovarian cancer. S Afr Med J 1987 May 16 1
7 7518445 Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3. J Biol Chem 1994 Jul 22 12
8 7537313 An enzyme-linked immunosorbent assay to identify inhibitors of activation of platelet integrin alpha IIb beta 3. J Immunol Methods 1995 Apr 12 2
9 7683418 Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. Proc Natl Acad Sci U S A 1993 May 1 2
10 8107850 Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. Nature 1994 Feb 17 1
11 8325838 Platelet-derived microparticle formation involves glycoprotein IIb-IIIa. Inhibition by RGDS and a Glanzmann's thrombasthenia defect. J Biol Chem 1993 Jul 15 3
12 8626452 The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J Biol Chem 1996 Mar 15 2
13 8703003 Ligand binding to integrin alphaIIbbeta3 is dependent on a MIDAS-like domain in the beta3 subunit. J Biol Chem 1996 Sep 6 1
14 8895766 Human prostate carcinoma cells express functional alphaIIb(beta)3 integrin. Cancer Res 1996 Nov 1 1
15 9001693 Platelet activation in newborns detected by flow-cytometry. Biol Neonate 1996 2
16 9013447 Differential regulation of the dual-specificity protein-tyrosine phosphatases CL100, B23, and PAC1 in mesangial cells. J Am Soc Nephrol 1997 Jan 1
17 9184418 Platelet hyporeactivity in very low birth weight neonates. Thromb Haemost 1997 May 1
18 9192835 The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells. Cancer Res 1997 Jun 15 5
19 9315536 Effect of Ca2+ on GP IIb-IIIa interactions with integrilin: enhanced GP IIb-IIIa binding and inhibition of platelet aggregation by reductions in the concentration of ionized calcium in plasma anticoagulated with citrate. Circulation 1997 Sep 2 2
20 9685382 A sequence within the cytoplasmic tail of GpIIb independently activates platelet aggregation and thromboxane synthesis. J Biol Chem 1998 Aug 7 1
21 9886908 Shear-induced platelet activation and platelet microparticle formation in native human blood. Thromb Res 1998 Dec 15 1
22 10030830 Cilostazol inhibits the expression of activation-dependent membrane surface glycoprotein on the surface of platelets stimulated in vitro. Thromb Res 1999 Feb 1 1
23 10375966 [Detection of activated platelets by flow cytometry]. Rinsho Byori 1999 May 4
24 10411706 Fibrinogen fragments and platelet dysfunction in uremia. Kidney Int 1999 Jul 2
25 10692478 Expression and function of calcium binding domain chimeras of the integrins alpha(IIb) and alpha(5). J Biol Chem 2000 Mar 3 2
26 11155036 Morphological differences between GPIb antibody-induced and shear stress-induced platelet aggregates. Haemostasis 2000 Jul-Aug 1
27 11390499 A filarial nematode-secreted phosphorylcholine-containing glycoprotein uncouples the B cell antigen receptor from extracellular signal-regulated kinase-mitogen-activated protein kinase by promoting the surface Ig-mediated recruitment of Src homology 2 domain-containing tyrosine phosphatase-1 and Pac-1 mitogen-activated kinase-phosphatase. J Immunol 2001 Jun 15 1
28 11533161 Effects of mutations within the herpes simplex virus type 1 DNA encapsidation signal on packaging efficiency. J Virol 2001 Oct 1
29 11560568 Recovery of platelet function after discontinuation of clopidogrel treatment in healthy volunteers. Br J Clin Pharmacol 2001 Sep 1
30 11682459 Role of von Willebrand factor in tumour cell-induced platelet aggregation: differential regulation by NO and prostacyclin. Br J Pharmacol 2001 Nov 1
31 11728532 Paradoxical activation of major platelet receptors in the methadone-maintained patients after single pill of aspirin. Thromb Res 2001 Nov 15 1
32 11841696 Megakaryothrombopoiesis during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin. Scand J Immunol 2002 Jan 2
33 11858493 Paradoxical platelet activation was not observed on dissociation of abciximab from GpIIb-IIIa complexes. Thromb Haemost 2002 Feb 1
34 11904526 Effects of combined therapy with clopidogrel and acetylsalicylic acid on platelet glycoprotein expression and aggregation. J Cardiovasc Pharmacol 2002 Apr 3
35 12413588 Resistance to aspirin in vitro is associated with increased platelet sensitivity to adenosine diphosphate. Thromb Res 2002 Jul 15 2
36 12567002 1H, 13C and 15N resonance assignments of the catalytic domain of human MAPK phosphatase, PAC-1. J Biomol NMR 2003 Jan 3
37 12574814 Activation-dependent surface expression of gC1qR/p33 on human blood platelets. Thromb Haemost 2003 Feb 1
38 12575935 Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP. Structure 2003 Feb 1
39 12591106 Effect of a single dose aspirin on platelets in humans with multiple risk factors for coronary artery disease. Eur J Pharmacol 2003 Feb 21 1
40 12944245 Paraformaldehyde fixation induces a systematic activation of platelets. Platelets 2003 Aug 1
41 14693172 Effects of the NHE-1 inhibitor cariporide alone or together with the P2Y12 antagonist AR-C 69331 MX on CD62p expression and formation of platelet-leukocyte aggregates. Thromb Res 2003 1
42 14717602 Redox modulation of integrin [correction of integin] alpha IIb beta 3 involves a novel allosteric regulation of its thiol isomerase activity. Biochemistry 2004 Jan 20 1
43 15075326 ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation. J Biol Chem 2004 Jun 25 1
44 15099972 The PAC-1 dual specificity phosphatase predicts poor outcome in serous ovarian carcinoma. Gynecol Oncol 2004 May 2
45 15156004 Is a 300 mg clopidogrel loading dose sufficient to inhibit platelet function early after coronary stenting? A platelet function profile study. J Invasive Cardiol 2004 Jun 1
46 15183041 Pharmacodynamic profile of antiplatelet agents: marked differences between single versus costimulation with platelet activators. Thromb Res 2004 1
47 15203712 Dextran 40 reduces in vitro platelet aggregation in peripheral arterial disease. Platelets 2004 Jun 1
48 15203718 Platelet activation markers, microparticles and soluble adhesion molecules are elevated in patients with arteriosclerosis obliterans: therapeutic effects by cilostazol and potentiation by dipyridamole. Platelets 2004 May 1
49 15528476 Sulfatides activate platelets through P-selectin and enhance platelet and platelet-leukocyte aggregation. Arterioscler Thromb Vasc Biol 2005 Jan 3
50 15546949 Differential requirements for calcium and Src family kinases in platelet GPIIb/IIIa activation and thromboxane generation downstream of different G-protein pathways. Blood 2005 Apr 1 1