prostaglandin I2 receptor ; Homo sapiens






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1 369163 Prostacyclin: a potent activator of human colonic adenylate cyclase activity. Z Gastroenterol 1978 Dec 1
2 1370696 Structure-activity relationships associated with 3,4,5-triphenyl-1H-pyrazole-1-nonanoic acid, a nonprostanoid prostacyclin mimetic. J Med Chem 1992 Jan 24 4
3 1375507 Prostacyclin analogues inhibit tissue factor expression in the human monocytic cell line THP-1 via a cyclic AMP-dependent mechanism. Arterioscler Thromb 1992 Jun 2
4 1632294 Platelet PGI2-receptor behaviour change after treatment with acetylsalicylic acid in healthy volunteers. Agents Actions Suppl 1992 3
5 1647965 Interactions between prostaglandin E2 and inhibitors of platelet aggregation which act through cyclic AMP. Eur J Pharmacol 1991 Feb 26 1
6 1710526 Octimibate, a potent non-prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor. Br J Pharmacol 1991 Jan 2
7 2043927 Primate vascular responses to octimibate, a non-prostanoid agonist at the prostacyclin receptor. Br J Pharmacol 1991 Jan 2
8 2428638 The putative prostacyclin receptor antagonist (FCE-22176) is a full agonist on human platelets and NCB-20 cells. Eur J Pharmacol 1986 Aug 7 1
9 2456096 Interaction between platelet receptor and iloprost isomers. Biochim Biophys Acta 1988 Jul 21 2
10 2465947 The platelet rebound phenomenon during PGI2-infusion occurs at the receptor level. Folia Haematol Int Mag Klin Morphol Blutforsch 1988 1
11 2477277 Induction of prostacyclin receptor expression in human erythroleukemia cells. FEBS Lett 1989 Sep 11 1
12 2847246 Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. Prostaglandins 1988 Jun 2
13 3026540 Prostaglandin endoperoxide analogues which are both thromboxane receptor antagonists and prostacyclin mimetics. Br J Pharmacol 1986 Mar 2
14 6087417 On the multiplicity of platelet prostaglandin receptors. II. The use of N-0164 for distinguishing the loci of action for PGI2, PGD2, PGE2 and hydantoin analogs. Prostaglandins 1984 May 1
15 6252573 On the multiplicity of platelet prostaglandin receptors. I. Evaluation of competitive antagonism by aggregometry. Prostaglandins 1980 May 1
16 7504734 Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5- oxazolyl]phenoxy]acetic acid. J Med Chem 1993 Nov 26 4
17 7507439 The effect of prostaglandins and thromboxane A2 on coronary vessel tone--mechanisms of action and therapeutic implications. Eur Heart J 1993 Nov 1
18 7508734 Two types of prostacyclin receptor coupling to stimulation of adenylate cyclase and phosphatidylinositol hydrolysis in a cultured mast cell line, BNu-2cl3 cells. Cell Signal 1993 Sep 2
19 7512962 Cloning and expression of a cDNA for the human prostanoid IP receptor. J Biol Chem 1994 Apr 22 1
20 7532011 Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL. Biochim Biophys Acta 1995 Feb 16 3
21 7543911 Platelet receptor desensitization induced by elevated prostacyclin levels causes platelet-endothelial cell adhesion. J Am Coll Cardiol 1995 Sep 1
22 7923647 Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system. Circulation 1994 Oct 5
23 8016389 Biochemical and pharmacological activity of arene-fused prostacyclin analogues on human platelets. Prostaglandins 1994 Mar 1
24 8023898 Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets. Am J Physiol 1994 Jun 1
25 8246157 Caffeine withdrawal: apparent heterologous sensitization to adenosine and prostacyclin actions in human platelets. J Pharmacol Exp Ther 1993 Nov 3
26 8254619 Nonprostanoid prostacyclin mimetics. 4. Derivatives of 2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid substituted alpha to the oxazole ring. J Med Chem 1993 Nov 26 1
27 8289201 FTIR spectral study of intramolecular hydrogen bonding in thromboxane A2 receptor agonist (U-46619), prostaglandin (PG)E2, PGD2, PGF2 alpha, prostacyclin receptor agonist (carbacyclin), and their related compounds in dilute CCl4 solution: structure-activity relationships. J Med Chem 1994 Jan 7 4
28 8552614 Loss of high-affinity prostacyclin receptors in platelets and the lack of prostaglandin-induced inhibition of platelet-stimulated thrombin generation in subjects with spinal cord injury. Proc Natl Acad Sci U S A 1996 Jan 9 2
29 8954139 Protein kinase C plays a key role in the cross-talk between intracellular signalings via prostanoid receptors in a megakaryoblastic cell line, MEG-01s. Biochim Biophys Acta 1996 Nov 22 2
30 9224631 Internalization and down-regulation of the prostacyclin receptor in human platelets. Biochem J 1997 Jul 1 1
31 9238054 Demonstration of a novel circulating anti-prostacyclin receptor antibody. Proc Natl Acad Sci U S A 1997 Aug 5 5
32 9264479 Prostacyclin receptor desensitization is a reversible phenomenon in human platelets. Circulation 1997 Aug 5 1
33 9758642 A major role for prostacyclin in nitric oxide-induced ocular vasorelaxation in the piglet. Circ Res 1998 Oct 5 1
34 9839547 Insulin-induced expression of prostacyclin receptors on platelets is mediated through ADP-ribosylation of Gi alpha protein. Life Sci 1998 1
35 10446129 The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling. J Biol Chem 1999 Aug 20 1
36 10632961 Phospholipase C activation by prostacyclin receptor agonist in cerebral microvascular smooth muscle cells. Proc Soc Exp Biol Med 2000 Jan 1
37 11015313 Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors. Br J Pharmacol 2000 Oct 2
38 11168298 Impaired platelet prostacyclin receptor activity: a monozygotic twin study discordant for spinal cord injury. Clin Physiol 2001 Jan 2
39 11309234 The effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP-receptor. Br J Pharmacol 2001 Apr 2
40 11682632 Activation of extracellular signal-regulated kinases and CREB/ATF-1 mediate the expression of CCAAT/enhancer binding proteins beta and -delta in preadipocytes. Mol Endocrinol 2001 Nov 1
41 11841567 Prostacyclin-induced rundown of N-methyl-D-aspartate receptor currents in HEK293 cells is protein kinase A-dependent and NR2 subunit-selective. J Neurochem 2002 Feb 1
42 11943879 Prostanoid signal integration and cross talk. Neurosignals 2002 Jan-Feb 1
43 11961139 The critical role of transmembrane prolines in human prostacyclin receptor activation. Mol Pharmacol 2002 May 1
44 12193530 A novel pathway of prostacyclin signaling-hanging out with nuclear receptors. Endocrinology 2002 Sep 1
45 12576509 Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J Lipid Res 2003 Feb 1
46 15056772 Temporal expression and signalling of prostacyclin receptor in the human endometrium across the menstrual cycle. Reproduction 2004 Jan 3
47 15194446 Role of extracellular cysteine residues in dimerization/oligomerization of the human prostacyclin receptor. Eur J Pharmacol 2004 Jun 21 1
48 15326037 Effect of the statin atorvastatin on intracellular signalling by the prostacyclin receptor in vitro and in vivo. Br J Pharmacol 2004 Sep 1
49 15469414 The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor. Biochem J 2005 Feb 15 1
50 15840408 Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes. Eur J Pharmacol 2005 Apr 11 1