prostaglandin I2 receptor ; Homo sapiens






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51 16078846 Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: synthesis, structure-activity relationship, and evaluation of benzofuran derivatives. J Med Chem 2005 Aug 11 3
52 16271145 A strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor. BMC Biochem 2005 Nov 4 3
53 16297632 Development of 3,4-dihydro-2H-benzo[1,4]oxazine derivatives as dual thromboxane A2 receptor antagonists and prostacyclin receptor agonists. Bioorg Med Chem 2006 Mar 15 1
54 16672356 Developmental regulation of prostacyclin synthase and prostacyclin receptors in the ovine uterus and conceptus during the peri-implantation period. Reproduction 2006 May 2
55 16723294 Morphologic changes in explanted lungs after prostacyclin therapy for pulmonary hypertension. Eur J Med Res 2006 May 5 2
56 16880763 Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations. Br J Pharmacol 2006 Sep 2
57 16885208 Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function. Mol Pharmacol 2006 Nov 1
58 16942748 Characterization of the molecular mechanisms of the coupling between intracellular loops of prostacyclin receptor with the C-terminal domain of the Galphas protein in human coronary artery smooth muscle cells. Arch Biochem Biophys 2006 Oct 1 1
59 17015447 Versatility and differential roles of cysteine residues in human prostacyclin receptor structure and function. J Biol Chem 2006 Dec 1 3
60 17106906 Asymmetric synthesis of 3-oxa-15-Deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin and its neuroprotective analogue 15-Deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin based on the conjugate addition-azoalkene-asymmetric olefination strategy. Chemistry 2007 1
61 17123841 BCP crystals increase prostacyclin production and upregulate the prostacyclin receptor in OA synovial fibroblasts: potential effects on mPGES1 and MMP-13. Osteoarthritis Cartilage 2007 Apr 1
62 17239589 Discovery and preliminary evaluation of 5-(4-phenylbenzyl)oxazole-4-carboxamides as prostacyclin receptor antagonists. Bioorg Med Chem Lett 2007 Mar 1 1
63 17496729 Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma. Pharmacogenet Genomics 2007 Apr 2
64 17764960 Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. Bioorg Med Chem 2007 Nov 1 2
65 17920266 Structure-activity relationship study on the 6-membered heteroaromatic ring system of diphenylpyrazine-type prostacyclin receptor agonists. Bioorg Med Chem Lett 2007 Dec 1 2
66 18221089 TP receptor as a therapeutic target in atherosclerosis and related cardiovascular diseases. Recent Pat Cardiovasc Drug Discov 2006 Nov 1
67 18323528 Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition. Circ Res 2008 Apr 25 1
68 18511850 Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells. Circ Res 2008 Jul 3 1
69 19033666 Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturition. J Clin Invest 2008 Dec 1
70 19302827 Novel signaling pathways promote a paracrine wave of prostacyclin-induced vascular smooth muscle differentiation. J Mol Cell Cardiol 2009 May 3
71 19880449 Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cells. J Immunol 2009 Nov 15 2
72 20085435 Prostacyclin receptor stimulation facilitates detection of human platelet P2Y(12) receptor inhibition by the PFA-100 system. Platelets 2010 1
73 20522800 Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease. Arterioscler Thromb Vasc Biol 2010 Sep 2
74 20631411 Regulation of cAMP by phosphodiesterases in erythrocytes. Pharmacol Rep 2010 May-Jun 2
75 21606930 Non-conventional hemostatic risk factors for coronary heart disease in individuals with spinal cord injury. Spinal Cord 2011 Aug 2
76 22159995 Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel. Am J Physiol Heart Circ Physiol 2012 Feb 1 1
77 22362844 Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension. Eur Respir J 2012 Oct 1
78 22480736 Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. Biochem Pharmacol 2012 Jul 1 3
79 22969152 Regulation of the human prostacyclin receptor gene by the cholesterol-responsive SREBP1. J Lipid Res 2012 Nov 5
80 23109431 New insights into structural determinants for prostanoid thromboxane A2 receptor- and prostacyclin receptor-G protein coupling. Mol Cell Biol 2013 Jan 1
81 23457445 Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1. PLoS One 2013 1
82 24392948 Selexipag for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother 2014 Feb 1
83 24450852 Prostacyclin signaling boosts NADPH oxidase 4 in the endothelium promoting cytoprotection and angiogenesis. Antioxid Redox Signal 2014 Jun 10 1
84 24682422 Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries. Naunyn Schmiedebergs Arch Pharmacol 2014 May 1
85 24954635 Expression profile and role of prostacyclin receptor (PTGIR) in peri-implantation porcine conceptuses. Theriogenology 2014 Sep 1 2
86 25082887 Beraprost sodium, a stable prostacyclin analogue, elicits dilation of isolated porcine retinal arterioles: roles of eNOS and potassium channels. Invest Ophthalmol Vis Sci 2014 Jul 31 2
87 25277144 Multiple-dose up-titration study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of selexipag, an orally available selective prostacyclin receptor agonist, in healthy subjects. Pharmacology 2014 1
88 25617843 Prostacyclin receptor expression on platelets of humans with type 2 diabetes is inversely correlated with hemoglobin A1c levels. Prostaglandins Other Lipid Mediat 2015 Jan-Mar 1
89 25850750 Pharmacokinetics and Tolerability of the Novel Oral Prostacyclin IP Receptor Agonist Selexipag. Am J Cardiovasc Drugs 2015 Jun 1
90 25851691 Effect of lopinavir/ritonavir on the pharmacokinetics of selexipag an oral prostacyclin receptor agonist and its active metabolite in healthy subjects. Br J Clin Pharmacol 2015 Oct 1
91 25936507 Prostacyclin receptors: Transcriptional regulation and novel signalling mechanisms. Prostaglandins Other Lipid Mediat 2015 Sep 1
92 26139576 Prostacyclin receptor (PTGIR) in the porcine endometrium: Regulation of expression and role in luminal epithelial and stromal cells. Theriogenology 2015 Oct 1 2
93 26152132 Bioequivalence of different dose-strength tablets of selexipag, a selective prostacyclin receptor agonist, in a multiple-dose up-titration study. Int J Clin Pharmacol Ther 2015 Sep 2
94 26261823 Expression of prostaglandin I2 (prostacyclin) receptor in blood of migraine patients: A potential biomarker. Adv Biomed Res 2015 1
95 26269890 Cytoprotective Role of Prostaglandin D<sub>2</sub> DP1 Receptor against Neuronal Injury Following Acute Excitotoxicity and Cerebral Ischemia 2015 2
96 26291199 Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. J Med Chem 2015 Sep 24 2
97 26846322 Selexipag: First Global Approval. Drugs 2016 Mar 1
98 26946143 Stimulation of fat storage by prostacyclin and selective agonists of prostanoid IP receptor during the maturation phase of cultured adipocytes. Cytotechnology 2016 Dec 2
99 27062188 Pharmacokinetics of the novel oral prostacyclin receptor agonist selexipag in subjects with hepatic or renal impairment. Br J Clin Pharmacol 2016 Aug 2
100 27063071 Investigation of Potential Pharmacodynamic and Pharmacokinetic Interactions Between Selexipag and Warfarin in Healthy Male Subjects. Clin Ther 2016 May 1