Title : Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5- oxazolyl]phenoxy]acetic acid.

Pub. Date : 1993 Nov 26

PMID : 7504734






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 These results suggest that the central oxazole ring of 11f is functioning as more than a simple scaffold that provides optimal stereodefinition for interaction with the PGI2 receptor. Oxazoles prostaglandin I2 receptor Homo sapiens
2 The nitrogen atom of the central heterocycle of 11f is postulated to engage in hydrogen-bond formation with a donor moiety in the PGI2 receptor protein, an interaction not available to 26 due to the markedly different topology. Nitrogen prostaglandin I2 receptor Homo sapiens
3 The affinities of 11f, 26, 31, 32, and 40 for the human platelet PGI2 receptor, determined by displacement of [3H]iloprost, correlated with inhibition of platelet function. Tritium prostaglandin I2 receptor Homo sapiens
4 The affinities of 11f, 26, 31, 32, and 40 for the human platelet PGI2 receptor, determined by displacement of [3H]iloprost, correlated with inhibition of platelet function. Iloprost prostaglandin I2 receptor Homo sapiens