serine palmitoyltransferase long chain base subunit 2 ; Homo sapiens






31 Article(s)
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1 8921873 Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase. Gene 1996 Oct 24 2
2 9133733 Serine palmitoyltransferase (scs1/lcb2) mutants have elevated copy number of the L-A dsRNA virus. Yeast 1997 Mar 30 1
3 9788249 UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes. J Lipid Res 1998 Oct 1
4 10971324 Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol 2000 Sep 1
5 12445191 Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis. J Invest Dermatol 2002 Nov 1
6 15679111 Nitric oxide regulates synthesis of gene products involved in keratinocyte differentiation and ceramide metabolism. Eur J Cell Biol 2004 Dec 2
7 17070807 Functional characterization of the promoter for the mouse SPTLC2 gene, which encodes subunit 2 of serine palmitoyltransferase. FEBS Lett 2006 Nov 13 1
8 19466436 Moisturizers change the mRNA expression of enzymes synthesizing skin barrier lipids. Arch Dermatol Res 2009 Sep 1
9 21618344 Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I. Hum Mutat 2011 Jun 1
10 22493506 Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction. J Biol Chem 2012 May 25 1
11 23658386 Hereditary sensory and autonomic neuropathy type 1 (HSANI) caused by a novel mutation in SPTLC2. Neurology 2013 Jun 4 1
12 24175284 The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutations. Biomed Res Int 2013 2
13 26573920 The Variant p.(Arg183Trp) in SPTLC2 Causes Late-Onset Hereditary Sensory Neuropathy. Neuromolecular Med 2016 Mar 2
14 26681808 HSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship. Hum Mol Genet 2016 Mar 1 2
15 28902413 Frequent genes in rare diseases: panel-based next generation sequencing to disclose causal mutations in hereditary neuropathies. J Neurochem 2017 Dec 1
16 29042446 Clinical and metabolic consequences of L-serine supplementation in hereditary sensory and autonomic neuropathy type 1C. Cold Spring Harb Mol Case Stud 2017 Nov 1
17 29778900 Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro. Neurobiol Dis 2018 Sep 1
18 30300355 Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents. PLoS One 2018 3
19 30952607 Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8<sup>+</sup> T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity 2019 May 21 2
20 30955194 A Novel Variant (Asn177Asp) in SPTLC2 Causing Hereditary Sensory Autonomic Neuropathy Type 1C. Neuromolecular Med 2019 Jun 2
21 31509666 Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. N Engl J Med 2019 Oct 10 1
22 32730653 Demyelination in hereditary sensory neuropathy type-1C. Ann Clin Transl Neurol 2020 Sep 1
23 33558761 Structural insights into the regulation of human serine palmitoyltransferase complexes. Nat Struct Mol Biol 2021 Mar 2
24 33662400 SSSPTA is essential for serine palmitoyltransferase function during development and hematopoiesis. J Biol Chem 2021 Jan-Jun 1
25 34302797 The role of the 'sphingoid motif' in shaping the molecular interactions of sphingolipids in biomembranes. Biochim Biophys Acta Biomembr 2021 Nov 1 4
26 34337561 An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions. Cell Rep Med 2021 Jul 20 3
27 34563520 Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts. J Lipid Res 2021 1
28 34785538 Serine palmitoyltransferase assembles at ER-mitochondria contact sites. Life Sci Alliance 2022 Feb 5
29 35239546 Deoxy-sphingolipids, oxidative stress, and vitamin C correlate with qualitative and quantitative patterns of small fiber dysfunction and degeneration. Pain 2022 Jan 19 1
30 35503173 Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases. Adv Exp Med Biol 2022 1
31 35513574 Upregulation of the serine palmitoyltransferase subunit SPTLC2 by endoplasmic reticulum stress inhibits the hepatic insulin response. Exp Mol Med 2022 May 1