Protein Name serine palmitoyltransferase long chain base subunit 2
Organism Homo sapiens
Gene ID 9517
Gene Symbol

SPTLC2

UniProt O15270 (SPTC2_HUMAN), A0A024R6H1 (A0A024R6H1_HUMAN)
Relationships Total Number of functionally related compound(s) : 25
Total Number of Articles : 31
Description

serine palmitoyltransferase long chain base subunit 2

Gene Summary

This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011]

synonyms
  • serine palmitoyltransferase 2
  • LCB 2
  • SPT 2
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Properties