Title : Upregulation of the serine palmitoyltransferase subunit SPTLC2 by endoplasmic reticulum stress inhibits the hepatic insulin response.

Pub. Date : 2022 May

PMID : 35513574






1 Functional Relationships(s)
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1 We found that the expression levels of Sptlc1 and Sptlc2, the major SPT subunits, were upregulated and that the cellular concentrations of ceramide and dihydroceramide were elevated by acute ER stress inducers in primary hepatocytes and HepG2 cells. Ceramides serine palmitoyltransferase long chain base subunit 2 Homo sapiens