SMAD family member 7 ; Mus musculus






160 Article(s)
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1 10393693 Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 1999 Jul 4
2 10781941 Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis. Mech Dev 2000 May 1
3 10995749 Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis. J Biol Chem 2000 Dec 8 3
4 11181520 Regulation and actions of Smad7 in the modulation of activin, inhibin, and transforming growth factor-beta signaling in anterior pituitary cells. Endocrinology 2001 Mar 1
5 12023024 Phosphorylation regulation of the interaction between Smad7 and activin type I receptor. FEBS Lett 2002 May 22 2
6 12149686 Murine nitrofen-induced pulmonary hypoplasia does not involve induction of TGF-beta signaling. J Pediatr Surg 2002 Aug 1
7 12839562 Sustained activation of fibroblast transforming growth factor-beta/Smad signaling in a murine model of scleroderma. J Invest Dermatol 2003 Jul 2
8 14633701 Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma. Cancer Res 2003 Nov 15 1
9 14732719 Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem 2004 Apr 9 1
10 14736011 Effects of candesartan, an angiotensin II type 1 receptor blocker, on diabetic nephropathy in KK/Ta mice. J Nephrol 2003 Nov-Dec 1
11 14742672 Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling. Mol Pharmacol 2004 Feb 1
12 15784120 Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling. Clin Exp Allergy 2005 Mar 1
13 15788474 Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7. J Am Soc Nephrol 2005 May 1
14 15963949 Inhibitory effect of genistein on mouse colon cancer MC-26 cells involved TGF-beta1/Smad pathway. Biochem Biophys Res Commun 2005 Aug 5 3
15 16410076 All-trans retinoic acid inhibited chondrogenesis of mouse embryonic palate mesenchymal cells by down-regulation of TGF-beta/Smad signaling. Biochem Biophys Res Commun 2006 Feb 17 8
16 16902401 Gene transfer of Smad7 modulates injury-induced conjunctival wound healing in mice. Mol Vis 2006 Aug 1 1
17 17087939 Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis. Gastroenterology 2006 Dec 9
18 17142077 Inhaled corticosteroid prevents the thickening of airway smooth muscle in murine model of chronic asthma. Pulm Pharmacol Ther 2008 1
19 17657819 Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. Hepatology 2007 Oct 1
20 18266971 Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice. J Cell Mol Med 2008 Oct 1
21 18336655 Transforming growth factor-beta and hepatocyte transdifferentiation in liver fibrogenesis. J Gastroenterol Hepatol 2008 Mar 1
22 18463324 Protective effect of COMP-angiopoietin-1 on cyclosporine-induced renal injury in mice. Nephrol Dial Transplant 2008 Sep 1
23 18539898 Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 2008 Aug 15 2
24 18602923 Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage. Gastroenterology 2008 Aug 2
25 18702012 TGF-beta1/Smad7 signaling stimulates renal tubulointerstitial fibrosis induced by AAI. J Recept Signal Transduct Res 2008 3
26 18948405 Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways. Endocrinology 2009 Mar 7
27 19079231 TGF-beta1 and Smad7 in the regulation of IBD. Mucosal Immunol 2008 Nov 2
28 19192480 Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology 2009 Apr 2
29 19515744 The latent form of transforming growth factor-beta administered orally is activated by gastric acid in mice. J Nutr 2009 Aug 1
30 19578745 Halofuginone mediated protection against radiation-induced leg contracture. Int J Oncol 2009 Aug 1
31 20040761 SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood 2010 Apr 1 2
32 20129692 TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I. J Hepatol 2010 Mar 1
33 20405019 In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. PLoS One 2010 Apr 13 1
34 20408897 Simvastatin induces Foxp3+ T regulatory cells by modulation of transforming growth factor-beta signal transduction. Immunology 2010 Aug 1
35 20427282 Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells. J Biol Chem 2010 Jun 25 1
36 20659902 Murine protein serine/threonine kinase 38 stimulates TGF-beta signaling in a kinase-dependent manner via direct phosphorylation of Smad proteins. J Biol Chem 2010 Oct 1 1
37 20973927 Allopurinol attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction. Cardiovasc Ther 2012 Apr 2
38 21189329 Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase. Cancer Res 2011 Feb 1 1
39 21203344 Therapeutic potential of trichostatin A to control inflammatory and fibrogenic disorders of the ocular surface. Mol Vis 2010 Dec 31 1
40 21214541 The effects of triptolide on airway remodelling and transforming growth factor-β₁/Smad signalling pathway in ovalbumin-sensitized mice. Immunology 2011 Mar 2
41 21386907 Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury. PLoS One 2011 Feb 28 3
42 21488083 Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice. Hepatology 2011 Jul 1
43 21931165 The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells. J Biol Chem 2011 Nov 25 2
44 22252452 Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease. Mol Ther 2012 Apr 2
45 22292409 [Mechanism of cleft palate in mice induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin]. Zhonghua Zheng Xing Wai Ke Za Zhi 2011 Nov 1
46 22314230 Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma. Int Immunopharmacol 2012 Apr 2
47 22326534 Candesartan antagonizes pressure overload-evoked cardiac remodeling through Smad7 gene-dependent MMP-9 suppression. Gene 2012 Apr 15 5
48 22433854 Sensitivity of heterozygous α1,6-fucosyltransferase knock-out mice to cigarette smoke-induced emphysema: implication of aberrant transforming growth factor-β signaling and matrix metalloproteinase gene expression. J Biol Chem 2012 May 11 1
49 22469817 Effects of Panax notoginseng flower extract on the TGF-β/Smad signal transduction pathway in heart remodeling of human chymase transgenic mice. Mol Med Rep 2012 Jun 1
50 22522482 Losartan, a therapeutic candidate in congenital muscular dystrophy: studies in the dy(2J) /dy(2J) mouse. Ann Neurol 2012 May 1