Title : Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury.

Pub. Date : 2011 Feb 28

PMID : 21386907






3 Functional Relationships(s)
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1 In addition, alcohol-induced liver injury and steatosis were profoundly aggravated in Smad7 deficient mice, associated with upregulation of critical genes involved in lipogenesis and inflammation. Alcohols SMAD family member 7 Mus musculus
2 Furthermore, alcohol-induced ADH1 expression was significantly abrogated by Smad7 deletion in hepatocytes. Alcohols SMAD family member 7 Mus musculus
3 CONCLUSION/SIGNIFICANCE: In this study, we provided in vivo evidence revealing that endogenous Smad7 plays an important role in liver function and alcohol-induced liver injury. Alcohols SMAD family member 7 Mus musculus