Title : Sustained activation of fibroblast transforming growth factor-beta/Smad signaling in a murine model of scleroderma.

Pub. Date : 2003 Jul

PMID : 12839562






2 Functional Relationships(s)
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1 Expression of Smad7, the endogenous inhibitor of transforming growth factor-beta/Smad signaling, was strongly induced in dermal cells by transforming growth factor-beta, but not by bleomycin injections. Bleomycin SMAD family member 7 Mus musculus
2 Collectively, these results indicate that bleomycin-induced murine scleroderma is associated with rapid and sustained induction of transforming growth factor-beta/Smad signaling in resident dermal fibroblasts. Bleomycin SMAD family member 7 Mus musculus