G protein-coupled receptor 84 ; Homo sapiens






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1 16966319 Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84. J Biol Chem 2006 Nov 10 5
2 18952326 Parenteral medium-chain triglyceride-induced neutrophil activation is not mediated by a Pertussis Toxin sensitive receptor. Clin Nutr 2009 Feb 1
3 19460454 Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. Prostaglandins Other Lipid Mediat 2009 Sep 1
4 21663979 Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends Pharmacol Sci 2011 Sep 1
5 23862620 Free fatty acids-sensing G protein-coupled receptors in drug targeting and therapeutics. Curr Med Chem 2013 1
6 25425658 Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84. J Biochem 2015 May 8
7 26962172 Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein-Coupled Receptor 84. J Pharmacol Exp Ther 2016 May 9
8 27326330 Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists. ACS Med Chem Lett 2016 Jun 9 3
9 27607913 Development of novel ligands for peptide GPCRs. Curr Opin Pharmacol 2016 Dec 1
10 27757764 Application of GPCR Structures for Modelling of Free Fatty Acid Receptors. Handb Exp Pharmacol 2017 1
11 28404994 Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression. Sci Rep 2017 Apr 12 2
12 28406627 Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84. J Med Chem 2017 May 11 3
13 29263400 Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84. Sci Rep 2017 Dec 20 7
14 29471103 Embelin and its derivatives unravel the signaling, proinflammatory and antiatherogenic properties of GPR84 receptor. Pharmacol Res 2018 May 4
15 29477577 Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R. Biochim Biophys Acta Mol Cell Res 2018 May 3
16 29775920 IL-33 stimulates expression of the GPR84 (EX33) fatty acid receptor gene and of cytokine and chemokine genes in human adipocytes. Cytokine 2018 Oct 2
17 30023867 6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84). ACS Omega 2018 Mar 31 4
18 30093459 PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway. J Pharmacol Exp Ther 2018 Oct 1
19 30108848 Succinct synthesis of saturated hydroxy fatty acids and <i>in vitro</i> evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84. Medchemcomm 2017 Jun 1 1
20 30753422 PBI-4050 reduces pulmonary hypertension, lung fibrosis, and right ventricular dysfunction in heart failure. Cardiovasc Res 2020 Jan 1 1
21 31465201 A Biased Agonist at Immunometabolic Receptor GPR84 Causes Distinct Functional Effects in Macrophages. ACS Chem Biol 2019 Sep 20 1
22 31721581 An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. J Med Chem 2020 Mar 12 5
23 32102673 Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84. Cell Commun Signal 2020 Feb 26 1
24 32719411 Regulatory role of Gpr84 in the switch of alveolar macrophages from CD11b<sup>lo</sup> to CD11b<sup>hi</sup> status during lung injury process. Mucosal Immunol 2020 Nov 2
25 33001759 20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor? DNA Cell Biol 2020 Nov 4
26 33267584 Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists. J Med Chem 2020 Dec 24 2
27 33359913 Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis. Pharmacol Res 2021 Feb 1
28 33789297 The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity. J Innate Immun 2021 15
29 33955686 Effect of GLPG1205, a GPR84 Modulator, on CYP2C9, CYP2C19, and CYP1A2 Enzymes: In Vitro and Phase 1 Studies. Clin Pharmacol Drug Dev 2021 Sep 1
30 34083384 Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells. Gut 2022 May 2
31 34208638 The Divergent Immunomodulatory Effects of Short Chain Fatty Acids and Medium Chain Fatty Acids. Int J Mol Sci 2021 Jun 16 1
32 34661077 Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84. ACS Pharmacol Transl Sci 2021 Oct 8 2
33 34912006 GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages. Acta Pharmacol Sin 2021 Dec 15 2
34 34968686 Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells. Pharmacol Res 2022 Feb 4
35 35427647 Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. J Biol Chem 2022 May 11