Pub. Date : 2015 May
PMID : 25425658
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GPR84 is a G protein-coupled receptor for medium-chain fatty acids. | medium-chain fatty acids | G protein-coupled receptor 84 | Homo sapiens |
| 2 | Capric acid and 3,3"-diindolylmethane are specific agonists for GPR84. | decanoic acid | G protein-coupled receptor 84 | Homo sapiens |
| 3 | Capric acid and 3,3"-diindolylmethane are specific agonists for GPR84. | 3,3'-diindolylmethane | G protein-coupled receptor 84 | Homo sapiens |
| 4 | We built a homology model of a GPR84-capric acid complex to investigate the ligand-binding mode using the crystal structure of human active-state beta2-adrenergic receptor. | decanoic acid | G protein-coupled receptor 84 | Homo sapiens |
| 5 | We compared the activity of the wild type and mutated forms of GPR84 by [(35)S]GTPgammaS binding to capric acid and diindolylmethane. | decanoic acid | G protein-coupled receptor 84 | Homo sapiens |
| 6 | We compared the activity of the wild type and mutated forms of GPR84 by [(35)S]GTPgammaS binding to capric acid and diindolylmethane. | 3,3'-diindolylmethane | G protein-coupled receptor 84 | Homo sapiens |
| 7 | Our molecular model provides an explanation for these results and interactions between GPR84 and capric acid. | decanoic acid | G protein-coupled receptor 84 | Homo sapiens |
| 8 | Further, from the results of a double stimulation assay, we concluded that diindolylmethane was a positive allosteric modulator for GPR84. | 3,3'-diindolylmethane | G protein-coupled receptor 84 | Homo sapiens |