Title : Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells.

Pub. Date : 2022 Feb

PMID : 34968686






4 Functional Relationships(s)
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Protein Name
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1 Although unrelated, hydroxycarboxylic acid receptor 3 (HCA3) and GPR84 share signaling via Galphai/o proteins and the agonist 3-hydroxydecanoate (3HDec). 3-Hydroxydecanoate G protein-coupled receptor 84 Homo sapiens
2 Although unrelated, hydroxycarboxylic acid receptor 3 (HCA3) and GPR84 share signaling via Galphai/o proteins and the agonist 3-hydroxydecanoate (3HDec). 3hdec G protein-coupled receptor 84 Homo sapiens
3 We show that activated GPR84 induces Galpha15-dependent ERK activation, increases intracellular Ca2+ and IP3 levels as well as ROS production. Inositol 1,4,5-Trisphosphate G protein-coupled receptor 84 Homo sapiens
4 We show that activated GPR84 induces Galpha15-dependent ERK activation, increases intracellular Ca2+ and IP3 levels as well as ROS production. ros G protein-coupled receptor 84 Homo sapiens