Pub. Date : 2021
PMID : 33789297
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neutrophils express the two formyl peptide receptors (FPR1 and FPR2) and the medium-chain fatty acid receptor GPR84. | Fatty Acids | G protein-coupled receptor 84 | Homo sapiens |
| 2 | In this study, we investigated the position of GPR84 in the FPR-defined hierarchy regarding the activation of neutrophil nicotine adenine dinucleotide phosphate (NADPH) oxidase, an enzyme system designed to generate reactive oxygen species (ROS), which are important regulators in cell signaling and immune regulation. | nicotine adenine dinucleotide phosphate | G protein-coupled receptor 84 | Homo sapiens |
| 3 | In this study, we investigated the position of GPR84 in the FPR-defined hierarchy regarding the activation of neutrophil nicotine adenine dinucleotide phosphate (NADPH) oxidase, an enzyme system designed to generate reactive oxygen species (ROS), which are important regulators in cell signaling and immune regulation. | NADP | G protein-coupled receptor 84 | Homo sapiens |
| 4 | In this study, we investigated the position of GPR84 in the FPR-defined hierarchy regarding the activation of neutrophil nicotine adenine dinucleotide phosphate (NADPH) oxidase, an enzyme system designed to generate reactive oxygen species (ROS), which are important regulators in cell signaling and immune regulation. | Reactive Oxygen Species | G protein-coupled receptor 84 | Homo sapiens |
| 5 | In this study, we investigated the position of GPR84 in the FPR-defined hierarchy regarding the activation of neutrophil nicotine adenine dinucleotide phosphate (NADPH) oxidase, an enzyme system designed to generate reactive oxygen species (ROS), which are important regulators in cell signaling and immune regulation. | Reactive Oxygen Species | G protein-coupled receptor 84 | Homo sapiens |
| 6 | When resting neutrophils were activated by GPR84 agonists, a modest ROS release was induced. | Reactive Oxygen Species | G protein-coupled receptor 84 | Homo sapiens |
| 7 | However, vast amounts of ROS were induced by these GPR84 agonists in FPR2-desensitized neutrophils, and the response was inhibited not only by a GPR84-specific antagonist but also by an FPR2-specific antagonist. | Reactive Oxygen Species | G protein-coupled receptor 84 | Homo sapiens |
| 8 | However, vast amounts of ROS were induced by these GPR84 agonists in FPR2-desensitized neutrophils, and the response was inhibited not only by a GPR84-specific antagonist but also by an FPR2-specific antagonist. | Reactive Oxygen Species | G protein-coupled receptor 84 | Homo sapiens |
| 9 | In contrast to FPR2-desensitized cells, FPR1 desensitization primarily resulted in a suppressed GPR84 agonist-induced ROS response, indicating a receptor hierarchical desensitization of GPR84 by FPR1-generated signals. | Reactive Oxygen Species | G protein-coupled receptor 84 | Homo sapiens |
| 10 | In contrast to FPR2-desensitized cells, FPR1 desensitization primarily resulted in a suppressed GPR84 agonist-induced ROS response, indicating a receptor hierarchical desensitization of GPR84 by FPR1-generated signals. | Reactive Oxygen Species | G protein-coupled receptor 84 | Homo sapiens |
| 11 | In summary, our data show that the two FPRs in human neutrophils control the NADPH oxidase activity with concomitant ROS production by communicating with GPR84 through different mechanisms. | Reactive Oxygen Species | G protein-coupled receptor 84 | Homo sapiens |
| 12 | While FPR1 desensitizes GPR84 and by that suppresses the release of ROS induced by GPR84 agonists, amplified ROS release is achieved by GPR84 agonists through reactivation of the desensitized FPR2. | Reactive Oxygen Species | G protein-coupled receptor 84 | Homo sapiens |
| 13 | While FPR1 desensitizes GPR84 and by that suppresses the release of ROS induced by GPR84 agonists, amplified ROS release is achieved by GPR84 agonists through reactivation of the desensitized FPR2. | Reactive Oxygen Species | G protein-coupled receptor 84 | Homo sapiens |
| 14 | While FPR1 desensitizes GPR84 and by that suppresses the release of ROS induced by GPR84 agonists, amplified ROS release is achieved by GPR84 agonists through reactivation of the desensitized FPR2. | Reactive Oxygen Species | G protein-coupled receptor 84 | Homo sapiens |
| 15 | While FPR1 desensitizes GPR84 and by that suppresses the release of ROS induced by GPR84 agonists, amplified ROS release is achieved by GPR84 agonists through reactivation of the desensitized FPR2. | Reactive Oxygen Species | G protein-coupled receptor 84 | Homo sapiens |