ubiquitin C-terminal hydrolase L1 ; Homo sapiens






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51 16642472 Silencing of the UCHL1 gene in human colorectal and ovarian cancers. Int J Cancer 2006 Sep 15 1
52 16888648 Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway. Cell Death Differ 2007 Mar 1
53 17259170 Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1. J Biol Chem 2007 Apr 6 1
54 17599367 DJ-1 and UCH-L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodents. Physiol Behav 2007 Sep 10 1
55 17929277 Human prostate cancer cells express neuroendocrine cell markers PGP 9.5 and chromogranin A. Prostate 2007 Dec 1 1
56 18499164 CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma. J Urol 2008 Jul 1
57 18616865 Depletion of intracellular zinc down-regulates expression of Uch-L1 mRNA and protein, and CREB mRNA in cultured hippocampal neurons. Nutr Neurosci 2008 Jun 2
58 18820707 Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis. Oncogene 2009 Jan 8 4
59 18949367 Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells. Int J Oncol 2008 Nov 1
60 19035457 Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells. Int J Cancer 2009 Feb 15 2
61 19141079 Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease. J Neurochem 2009 Feb 1
62 19261853 Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease. Proc Natl Acad Sci U S A 2009 Mar 24 1
63 20104524 Silencing of the UCHL1 gene in giant cell tumors of bone. Int J Cancer 2010 Oct 15 1
64 20231490 Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1. Proc Natl Acad Sci U S A 2010 Apr 13 8
65 20439756 Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc Natl Acad Sci U S A 2010 May 18 2
66 20524644 Proteomic and mass spectroscopic quantitation of protein S-nitrosation differentiates NO-donors. ACS Chem Biol 2010 Jul 16 1
67 21298373 Backbone and side-chain 1H, 15N and 13C resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1. Biomol NMR Assign 2011 Oct 3
68 21751238 Involvement of ubiquitin-proteasome system in icariin-induced cardiomyocyte differentiation of embryonic stem cells using two-dimensional gel electrophoresis. J Cell Biochem 2011 Nov 3
69 21851340 Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains. Biochem J 2012 Jan 1 1
70 21878121 Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma. J Exp Clin Cancer Res 2011 Aug 30 2
71 21897042 Grape seed procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products. Biosci Biotechnol Biochem 2011 5
72 22001920 The serine protease HtrA2 cleaves UCH-L1 and inhibits its hydrolase activity: implication in the UCH-L1-mediated cell death. Biochem Biophys Res Commun 2011 Nov 11 2
73 22142694 Galangin induces apoptosis in gastric cancer cells via regulation of ubiquitin carboxy-terminal hydrolase isozyme L1 and glutathione S-transferase P. Food Chem Toxicol 2012 Mar 2
74 22246902 Tumor suppressor function of PGP9.5 is associated with epigenetic regulation in prostate cancer--novel predictor of biochemical recurrence after radical surgery. Cancer Epidemiol Biomarkers Prev 2012 Mar 1
75 22284438 Contribution of active site glutamine to rate enhancement in ubiquitin C-terminal hydrolases. FEBS J 2012 Mar 1
76 22507762 Psychotropic drug effects on gene transcriptomics relevant to Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry 2012 Aug 7 1
77 22617491 The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorg Med Chem Lett 2012 Jun 15 8
78 22883340 [The role of hypermethylation in promoter region of ubiquitin carboxyl-terminal hydrolase L1 in human esophageal cancer]. Zhonghua Nei Ke Za Zhi 2012 May 1
79 22905785 Effects of ovariectomy and dehydroepiandrosterone (DHEA) on vaginal wall thickness and innervation. J Sex Med 2012 Oct 2
80 23291960 Ubiquitin carboxy-terminal hydrolase L1 may be involved in the development of mammary phyllodes tumors. Virchows Arch 2013 Feb 1
81 23416043 β-Amyloid-aluminum complex alters cytoskeletal stability and increases ROS production in cortical neurons. Neurochem Int 2013 Apr 1
82 23490535 Phosphodiesterase type 1, calcitonin gene-related peptide and vasoactive intestinal polypeptide are involved in the control of human vaginal arterial vessels. Eur J Obstet Gynecol Reprod Biol 2013 Jul 2
83 23499448 Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA. Cell Rep 2013 Mar 28 1
84 23555160 Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids. World J Gastroenterol 2013 Mar 21 1
85 23717208 Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response. PLoS Pathog 2013 2
86 24020190 [Application of the immunohistochemical detection of PGP 9.5 protein for the study of rat and human heart innervation]. Morfologiia 2013 1
87 24080464 Elevated serum ubiquitin C-terminal hydrolase-L1 levels in patients with carbon monoxide poisoning. Clin Biochem 2014 Jan 1
88 24139494 Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis. J Allergy Clin Immunol 2014 May 1
89 24525247 Ubiquitin C-terminal hydrolase L1 interacts with choline transporter in cholinergic cells. Neurosci Lett 2014 Apr 3 1
90 24582816 Glutathione-mediated reversibility of covalent modification of ubiquitin carboxyl-terminal hydrolase L1 by 1,2-naphthoquinone through Cys152, but not Lys4. Chem Biol Interact 2014 May 5 16
91 24583340 UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation. Biochim Biophys Acta 2014 Jul 1
92 24832624 Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function. J Neurochem 2014 Sep 1
93 24879150 UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy. Autophagy 2014 Jun 1
94 24959670 N-terminal truncated UCH-L1 prevents Parkinson's disease associated damage. PLoS One 2014 7
95 25638021 Potential of UCHL1 as biomarker for destruction of pancreatic beta cells. J Proteomics 2015 Mar 18 6
96 25687137 NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease. Hum Mol Genet 2015 Jun 1 2
97 25915537 Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4. Oncotarget 2015 Jun 30 1
98 26018507 The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways. Tumour Biol 2015 Nov 1
99 26293643 Overexpression of ubiquitin carboxyl terminal hydrolase-L1 enhances multidrug resistance and invasion/metastasis in breast cancer by activating the MAPK/Erk signaling pathway. Mol Carcinog 2016 Sep 2
100 26405262 Is the protein expression window during testicular development affected in patients at risk for stem cell loss? Hum Reprod 2015 Dec 2