Pub. Date : 2011
PMID : 21897042
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The objective of this present study was to determine whether GSPB2 (grape seed procyanidin B2), which is a dimeric procyanidin and more biologically active, could inhibit AGE-induced VSMC proliferation by affecting the production of ubiquitin COOH-terminal hydrolase 1 (UCH-L1), the degradation of IkappaB-alpha and nuclear translocation of NF-kappaB in human aortic smooth muscle cells (HASMCs). | procyanidin B2 | ubiquitin C-terminal hydrolase L1 | Homo sapiens |
| 2 | The objective of this present study was to determine whether GSPB2 (grape seed procyanidin B2), which is a dimeric procyanidin and more biologically active, could inhibit AGE-induced VSMC proliferation by affecting the production of ubiquitin COOH-terminal hydrolase 1 (UCH-L1), the degradation of IkappaB-alpha and nuclear translocation of NF-kappaB in human aortic smooth muscle cells (HASMCs). | procyanidin B2 | ubiquitin C-terminal hydrolase L1 | Homo sapiens |
| 3 | The objective of this present study was to determine whether GSPB2 (grape seed procyanidin B2), which is a dimeric procyanidin and more biologically active, could inhibit AGE-induced VSMC proliferation by affecting the production of ubiquitin COOH-terminal hydrolase 1 (UCH-L1), the degradation of IkappaB-alpha and nuclear translocation of NF-kappaB in human aortic smooth muscle cells (HASMCs). | procyanidin | ubiquitin C-terminal hydrolase L1 | Homo sapiens |
| 4 | The objective of this present study was to determine whether GSPB2 (grape seed procyanidin B2), which is a dimeric procyanidin and more biologically active, could inhibit AGE-induced VSMC proliferation by affecting the production of ubiquitin COOH-terminal hydrolase 1 (UCH-L1), the degradation of IkappaB-alpha and nuclear translocation of NF-kappaB in human aortic smooth muscle cells (HASMCs). | procyanidin | ubiquitin C-terminal hydrolase L1 | Homo sapiens |
| 5 | These results collectively suggest that AGE-induced HASMC proliferation and migration was suppressed by GSPB2 through regulating UCH-L1 and ubiquitination of IkappaB-alpha. | hasmc | ubiquitin C-terminal hydrolase L1 | Homo sapiens |