phosphodiesterase 7A ; Homo sapiens






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1 6490655 Synthesis of a model protein of defined secondary and quaternary structure. Effect of chain length on the stabilization and formation of two-stranded alpha-helical coiled-coils. J Biol Chem 1984 Nov 10 2
2 9195912 Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart. J Biol Chem 1997 Jun 27 3
3 9618252 Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. Biochem Biophys Res Commun 1998 May 29 2
4 9922221 Identification and function of cyclic nucleotide phosphodiesterase isoenzymes in airway epithelial cells. Am J Respir Cell Mol Biol 1999 Feb 3
5 9933169 CD3- and CD28-dependent induction of PDE7 required for T cell activation. Science 1999 Feb 5 7
6 10691694 Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: first phosphodiesterase 7 inhibitors. J Med Chem 2000 Feb 24 3
7 10814504 Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun 2000 May 19 1
8 11282454 Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis. Cell Signal 2001 Mar 1
9 11327595 Synthesis and structure-activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors. Bioorg Med Chem Lett 2001 Apr 23 1
10 11448460 Regulatory roles of adenylate cyclase and cyclic nucleotide phosphodiesterases 1 and 4 in interleukin-13 production by activated human T cells. Biochem Pharmacol 2001 Aug 15 1
11 11812656 PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP. Cell Signal 2002 Mar 10
12 12067300 Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors. Clin Exp Immunol 2002 Jun 3
13 12842049 Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity. Structure 2003 Jul 5
14 12895443 Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization. Exp Neurol 2003 Aug 1
15 15125967 Identification of purine inhibitors of phosphodiesterase 7 (PDE7). Bioorg Med Chem Lett 2004 Jun 7 2
16 15324874 Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies. Bioorg Med Chem Lett 2004 Sep 20 1
17 15324875 Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives. Bioorg Med Chem Lett 2004 Sep 20 1
18 15324876 Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1. Bioorg Med Chem Lett 2004 Sep 20 2
19 15324877 Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives. Bioorg Med Chem Lett 2004 Sep 20 2
20 15371556 Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol Pharmacol 2004 Dec 1
21 15470020 A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines. J Immunol 2004 Oct 15 2
22 15627479 Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells. Biochem Pharmacol 2005 Jan 15 1
23 15670947 Synthesis, biological evaluation and molecular modelling studies on benzothiadiazine derivatives as PDE4 selective inhibitors. Bioorg Med Chem 2005 Feb 15 2
24 15780616 Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships. Bioorg Med Chem Lett 2005 Apr 1 3
25 16427796 Phosphodiesterase (PDE) 7 in inflammatory cells from patients with asthma and COPD. Pulm Pharmacol Ther 2007 3
26 16458289 Phosphodiesterase inhibitors in airways disease. Eur J Pharmacol 2006 Mar 8 2
27 18082290 CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example. Eur J Med Chem 2008 Jul 1
28 18366018 Stereoelectronic properties of spiroquinazolinones in differential PDE7 inhibitory activity. J Comput Chem 2008 Sep 5
29 18420479 Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts. Bone 2008 Jul 3
30 19033455 Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2008 Dec 9 1
31 19195485 ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-gamma production by mouse activated T lymphocytes. Immunol Lett 2009 Feb 21 2
32 19272774 Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation. Bioorg Med Chem Lett 2009 Apr 1 3
33 20132810 Phosphodiesterase 7A inhibitor ASB16165 impairs proliferation of keratinocytes in vitro and in vivo. Eur J Pharmacol 2010 May 10 7
34 21118717 Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases. Cell Signal 2011 Mar 2
35 21205923 GSK256066, an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 suitable for administration by inhalation: in vitro, kinetic, and in vivo characterization. J Pharmacol Exp Ther 2011 Apr 1
36 21983442 Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors. Bioorg Med Chem Lett 2011 Nov 15 1
37 22100138 Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. Eur J Med Chem 2012 Jan 4
38 22306656 5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3β (GSK-3β) and phosphodiesterase 7 (PDE7) inhibitors: determination of blood-brain barrier penetration and binding to human serum albumin. Eur J Pharm Sci 2012 Apr 11 7
39 23570245 New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders. Expert Opin Drug Discov 2013 Jun 4
40 23661015 Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival. Cell Mol Life Sci 2013 Sep 1
41 23709025 Enzyme assays for cGMP hydrolyzing phosphodiesterases. Methods Mol Biol 2013 1
42 24437940 Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders. ACS Chem Neurosci 2014 Mar 19 4
43 24838636 Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold. Org Biomol Chem 2014 Jun 28 1
44 25128584 PDE7A1 hydrolyzes cCMP. FEBS Lett 2014 Sep 17 1
45 25264825 Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors. J Med Chem 2014 Oct 23 4
46 25284693 cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases. Expert Opin Ther Pat 2014 Dec 2
47 25383422 Discovery of 2-(cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as a new series of potent phosphodiesterase 7 inhibitors. J Med Chem 2014 Dec 11 1
48 25529739 Discovery and SAR study of 2-(4-pyridylamino)thieno[3,2-d]pyrimidin-4(3H)-ones as soluble and highly potent PDE7 inhibitors. Bioorg Med Chem Lett 2015 Feb 1 2
49 26022351 Inhibition of breast cancer cell migration by activation of cAMP signaling. Breast Cancer Res Treat 2015 Jul 1
50 28093982 PDE7-Selective and Dual Inhibitors: Advances in Chemical and Biological Research. Curr Med Chem 2017 6