N-palmitoylsphingosine






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1 9691465 Ceramides perturb the structure of phosphatidylcholine bilayers and modulate the activity of phospholipase A2. Eur Biophys J 1998 1
2 10395296 Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts. J Cell Physiol 1999 Aug 1
3 11096096 Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes. J Biol Chem 2001 Mar 16 1
4 11287428 Ceramide enables fas to cap and kill. J Biol Chem 2001 Jun 29 1
5 12829737 Disruption of lipid order by short-chain ceramides correlates with inhibition of phospholipase D and downstream signaling by FcepsilonRI. J Cell Sci 2003 Aug 1 1
6 14563411 Ceramide induces translocation of protein kinase C-alpha to the Golgi compartment of human embryonic kidney cells by interacting with the C2 domain. Biochim Biophys Acta 2003 Oct 20 1
7 15596449 CERT mediates intermembrane transfer of various molecular species of ceramides. J Biol Chem 2005 Feb 25 2
8 15743760 Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane. J Biol Chem 2005 May 27 2
9 15946935 Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem 2005 Jul 29 8
10 16118219 SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem 2005 Nov 4 1
11 16170023 Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Mol Cancer Ther 2005 Sep 1
12 16636669 TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis. Oncogene 2006 Sep 14 1
13 17030510 Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. J Biol Chem 2006 Dec 1 2
14 17982273 Mechanism of homocysteine-induced Rac1/NADPH oxidase activation in mesangial cells: role of guanine nucleotide exchange factor Vav2. Cell Physiol Biochem 2007 4
15 18400537 De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prostaglandins Other Lipid Mediat 2008 Jun 4
16 18682390 Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity. J Biol Chem 2008 Oct 24 1
17 19137010 Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. Oncogene 2009 Feb 26 4
18 19723703 Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J 2010 Jan 8
19 20808818 Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One 2010 Aug 19 1
20 20941382 Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One 2010 Sep 30 1
21 21490809 C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing. J Lipids 2011 1
22 22615346 Identification and characterization of protein phosphatase 2C activation by ceramide. J Lipid Res 2012 Aug 2
23 22640955 Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis. Free Radic Biol Med 2012 Aug 15 1
24 23283968 Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain. J Biol Chem 2013 Feb 15 1
25 23290776 Diverse functions of ceramide in cancer cell death and proliferation. Adv Cancer Res 2013 3
26 23519469 Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6. J Biol Chem 2013 May 3 2
27 23690971 Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models. PLoS One 2013 1
28 24019516 Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization. J Biol Chem 2013 Oct 25 1
29 24595304 Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics. Am J Physiol Endocrinol Metab 2014 May 1 1
30 24632610 Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility. Oncogene 2015 Feb 19 1
31 24819607 New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway. Autophagy 2014 Jul 1
32 25295789 CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. Cell Metab 2014 Oct 7 3
33 25462172 Very long chain ceramides interfere with C16-ceramide-induced channel formation: A plausible mechanism for regulating the initiation of intrinsic apoptosis. Biochim Biophys Acta 2015 Feb 2
34 25839235 Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner. J Biol Chem 2015 May 22 1
35 26318452 Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. J Biol Chem 2015 Oct 16 1
36 26783755 Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner. PLoS One 2016 3
37 26933996 Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. Oncotarget 2016 Apr 5 1
38 27280497 LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity. Curr Mol Med 2016 2
39 27551447 Stereospecific induction of apoptosis in tumor cells via endogenous C16-ceramide and distinct transcripts. Cell Death Discov 2015 1
40 28179144 Plasma membrane reorganization links acid sphingomyelinase/ceramide to p38 MAPK pathways in endothelial cells apoptosis. Cell Signal 2017 May 1
41 29138469 Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis. Sci Rep 2017 Nov 14 2
42 29374263 Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis. Sci Rep 2018 Jan 26 1
43 29472233 Novel Role of IL (Interleukin)-1β in Neutrophil Extracellular Trap Formation and Abdominal Aortic Aneurysms. Arterioscler Thromb Vasc Biol 2018 Apr 2
44 30131496 A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nat Commun 2018 Aug 21 1
45 30226616 C16‑ceramide and sphingosine 1‑phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation. Oncol Rep 2018 Nov 3
46 30297838 C<sub>16</sub>-ceramide is a natural regulatory ligand of p53 in cellular stress response. Nat Commun 2018 Oct 8 4
47 30836822 Expression of the SNAI2 transcriptional repressor is regulated by C<sub>16</sub>-ceramide. Cancer Biol Ther 2019 8
48 31585804 Sildenafil Protects Endothelial Cells From Radiation-Induced Oxidative Stress. J Sex Med 2019 Nov 2
49 31744877 Ceramide Analogue SACLAC Modulates Sphingolipid Levels and <i>MCL-1</i> Splicing to Induce Apoptosis in Acute Myeloid Leukemia. Mol Cancer Res 2020 Mar 2
50 32045989 Transcriptomics Reveal Altered Metabolic and Signaling Pathways in Podocytes Exposed to C16 Ceramide-Enriched Lipoproteins. Genes (Basel) 2020 Feb 7 2